The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …

Cognition can be defined as computation over meaningful representations in the brain to
produce adaptive behaviour. There are two views on the relationship between cognition and …

The medial entorhinal cortex is part of a neural system for map** the position of an
individual within a physical environment. Grid cells, a key component of this system, fire in a …

We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution,
multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a …

Deep neural networks have achieved impressive successes in fields ranging from object
recognition to complex games such as Go,. Navigation, however, remains a substantial …

During spatial navigation, neural activity in the hippocampus and the medial entorhinal
cortex (MEC) is correlated to navigational variables such as location,, head direction, speed …

Since the first place cell was recorded and the cognitive-map theory was subsequently
formulated, investigation of spatial representation in the hippocampal formation has evolved …

An organism's survival can depend on its ability to recall and navigate to spatial locations
associated with rewards, such as food or a home. Accumulating research has revealed that …

Grid cells in the medial entorhinal cortex have spatial firing fields that repeat periodically in a
hexagonal pattern. When animals move, activity is translated between grid cells in …

The discovery of neuronal systems dedicated to computing spatial information, composed of
functionally distinct cell types such as place and grid cells, combined with an extensive body …