From bacteria to plants and humans, the glutathione system plays a pleiotropic role in cell
defense against metabolic, oxidative and metal stresses. Glutathione (GSH), the γ-L …

The redox states of the NAD and NADP pyridine nucleotide pools play critical roles in
defining the activity of energy producing pathways, in driving oxidative stress and in …

NAD is a key determinant of cellular energy metabolism. In contrast, its phosphorylated form,
NADP, plays a central role in biosynthetic pathways and antioxidant defence. The reduced …

Rationale: Cardiac aging is an important contributing factor for heart failure, which affects a
large population but remains poorly understood. Objective: The purpose of this study is to …

The use of natural catalysts-enzymes-for the transformation of nonnatural man-made
organic compounds is not at all new: they have been used for more than one hundred years …

Pollution, accidents, and misinformation have earned the pharmaceutical and chemical
industry a poor public reputation, despite their undisputable importance to society …

Understanding molecular recognition is of fundamental importance in applications such as
therapeutics, chemical catalysis and sensor design. The most common recognition motifs …

▪ Abstract Nitrate reductase (NR; EC 1.6. 6.1-3) catalyzes NAD (P) H reduction of nitrate to
nitrite. NR serves plants, algae, and fungi as a central point for integration of metabolism by …

In the pathways of steroid hormone biosynthesis there are two major types of enzymes:
cytochromes P450 and other steroid oxidoreductases. This review presents an overview of …

The entire pathway of palmitate synthesis from malonyl-CoA in mammals is catalyzed by a
single, homodimeric, multifunctional protein, the fatty acid synthase. Each subunit contains …