Hypertension is a leading risk factor for stroke, heart disease and chronic kidney disease.
Multiple interacting factors and organ systems increase blood pressure and cause target …

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and its prevalence
increases with age. The irregular and rapid contraction of the atria can lead to ineffective …

The development of essential hypertension involves several factors. Vascular dysfunction,
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …

Epithelial sodium channels (ENaC) are part of a complex network of interacting biochemical
pathways and as such are involved in several disease states. Dependent on site and type of …

Precision medicine is envisioned as the future of cardiovascular healthcare, offering a more
tailored and effective method for managing cardiovascular diseases compared to the …

Introduction Aging increases the risk of atherosclerotic vascular disease and its
complications. Macrophages are pivotal in the pathogenesis of vascular aging, driving …

Hypertension, a multifaceted cardiovascular disorder influenced by genetic, epigenetic, and
environmental factors, poses a significant risk for the development of coronary artery …

Abstract The epithelial Na+ channel (ENaC) is traditionally composed of three subunits,
although non‐canonical expression has been found in various tissues including the …

This review highlights the molecular basis of salt sensitivity in hypertension, with a focus on
the regulation of sodium transport in the distal nephron. Sodium reabsorption in this region …

Vascular inflammation underlies the development of hypertension, and the mechanisms by
which it increases blood pressure remain the topic of intense investigation. Proinflammatory …