The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Many human brain disorders are associated with characteristic alterations in the structural
and functional connectivity of the brain. In this article, we explore how commonalities and …

Epidemiological studies identify midlife hearing loss as an independent risk factor for
dementia, estimated to account for 9% of cases. We evaluate candidate brain bases for this …

Pathological perturbations of the brain are rarely confined to a single locus; instead, they
often spread via axonal pathways to influence other regions. Patterns of such disease …

Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …

Modern network science has revealed fundamental aspects of normal brain-network
organization, such as small-world and scale-free patterns, hierarchical modularity, hubs and …

Virtually all domains of cognitive function require the integration of distributed neural activity.
Network analysis of human brain connectivity has consistently identified sets of regions that …

Brain networks or 'connectomes' include a minority of highly connected hub nodes that are
functionally valuable, because their topological centrality supports integrative processing …

Network studies of large-scale brain connectivity have begun to reveal attributes that
promote the segregation and integration of neural information: communities and hubs …

Alzheimer's disease (AD) is the most common neurodegenerative disease among the
elderly with a progressive decline in cognitive function significantly affecting quality of life …