Preservation of mitochondrial health in liver ischemia/reperfusion injury
Liver ischemia-reperfusion injury (LIRI) is a major cause of the development of
complications in different clinical settings such as liver resection and liver transplantation …
complications in different clinical settings such as liver resection and liver transplantation …
The current role and future applications of machine perfusion in liver transplantation
The relative paucity of donor livers suitable for transplantation has sparked innovations to
preserve and recondition organs to expand the pool of transplantable organs. Currently …
preserve and recondition organs to expand the pool of transplantable organs. Currently …
Transcriptomic signatures during normothermic liver machine perfusion correspond with graft quality and predict the early graft function
Background A better understanding of the molecular events during liver normothermic
machine perfusion (NMP) is warranted to develop a data-based approach for the …
machine perfusion (NMP) is warranted to develop a data-based approach for the …
Assessment of liver graft quality during hypothermic oxygenated perfusion: the first international validation study
Background & Aims While it is currently assumed that liver assessment is only possible
during normothermic machine perfusion, there is uncertainty regarding a reliable and quick …
during normothermic machine perfusion, there is uncertainty regarding a reliable and quick …
A proof-of-concept study in small and large animal models for coupling liver normothermic machine perfusion with mesenchymal stromal cell bioreactors
To fully harness mesenchymal-stromal-cells (MSCs)'benefits during Normothermic Machine
Perfusion (NMP), we developed an advanced NMP platform coupled with a MSC-bioreactor …
Perfusion (NMP), we developed an advanced NMP platform coupled with a MSC-bioreactor …
Back to basics: Liver graft ischemia in the era of machine perfusion
X Muller, G Rossignol, K Mohkam, JY Mabrut - Transplantation, 2024 - journals.lww.com
GRAFT ISCHEMIA IN LT There are 3 main ischemic phases to which the liver graft is
exposed during the procurement and preservation process: donor warm ischemia (DWI) …
exposed during the procurement and preservation process: donor warm ischemia (DWI) …
Real-time monitoring of mitochondrial oxygenation during machine perfusion using resonance Raman spectroscopy predicts organ function
Organ transplantation is a life-saving procedure affecting over 100,000 people on the
transplant waitlist. Ischemia reperfusion injury (IRI) is a major challenge in the field as it can …
transplant waitlist. Ischemia reperfusion injury (IRI) is a major challenge in the field as it can …
Twelve-hour normothermic liver perfusion in a rat model: characterization of the changes in the ex-situ bio-molecular phenotype and metabolism
The partial understanding of the biological events that occur during normothermic machine
perfusion (NMP) and particularly during prolonged perfusion might hinder its deployment in …
perfusion (NMP) and particularly during prolonged perfusion might hinder its deployment in …
Differential production of mitochondrial reactive oxygen species between mouse (Mus musculus) and crucian carp (Carassius carassius)
Aim In most vertebrates, oxygen deprivation and subsequent re‐oxygenation are associated
with mitochondrial impairment and excess production of reactive oxygen species (ROS) like …
with mitochondrial impairment and excess production of reactive oxygen species (ROS) like …
[HTML][HTML] Machine Perfusion as a Strategy to Decrease Ischemia-Reperfusion Injury and Lower Cancer Recurrence Following Liver Transplantation
Liver transplantation (LT) is a key treatment for primary and secondary liver cancers,
reducing tumor burden with concurrent improvement of liver function. While significant …
reducing tumor burden with concurrent improvement of liver function. While significant …