The understanding of complex inhalation and transport processes of pollutant particles
through the human respiratory system is important for investigations into dosimetry and …

Background and objectives Suspended respirable airborne particles are associated with
human health risks and especially particles within the range of ultrafine (< 0.1 μm) or fine (< …

TAVR has emerged as a standard approach for treating severe aortic stenosis patients.
However, it is associated with several clinical complications, including subclinical leaflet …

This study presents a novel coupled computational fluid dynamics-discrete element method
(CFD-DEM) model for simulating airflow and inhaled particle dynamics in the nasal cavity …

Abstract Background Computational Fluid-Particle Dynamics (CFPD) models have been
employed to predict lung aerosol dynamics for decades, estimating the delivery efficiency of …

Deposition of polydisperse particles representing nasal spray application in a human nasal
cavity was performed under transient breathing profiles of sniffing, constant flow, and breath …

This study identifies anatomical and airflow-induced relationships based on nasal
morphological variations due to inter-and intra-racial differences and gender. Subject …

Targeted nasal drug delivery can provide improved efficacy for drug formulations to be
delivered at high efficacy rates. Some parameters that influence drug delivery have a …

Regulatory agencies are considering alternative approaches to assessing inhalation toxicity
that utilizes in vitro studies with human cells and in silico modeling in lieu of additional …

Part of the effective prediction of the pharmacokinetics of drugs (or toxic particles) requires
extrapolation of experimental data sets from animal studies to humans. As the respiratory …