The understanding of complex inhalation and transport processes of pollutant particles
through the human respiratory system is important for investigations into dosimetry and …

Abstract Background Computational Fluid-Particle Dynamics (CFPD) models have been
employed to predict lung aerosol dynamics for decades, estimating the delivery efficiency of …

Deposition of polydisperse particles representing nasal spray application in a human nasal
cavity was performed under transient breathing profiles of sniffing, constant flow, and breath …

This study identifies anatomical and airflow-induced relationships based on nasal
morphological variations due to inter-and intra-racial differences and gender. Subject …

Background and objectives Suspended respirable airborne particles are associated with
human health risks and especially particles within the range of ultrafine (< 0.1 μm) or fine (< …

Part of the effective prediction of the pharmacokinetics of drugs (or toxic particles) requires
extrapolation of experimental data sets from animal studies to humans. As the respiratory …

Exposures to airborne particles and toxic gases generated by welding fabrication activities
will potentially lead to various diseases. Accurate information on the transport and …

Regulatory agencies are considering alternative approaches to assessing inhalation toxicity
that utilizes in vitro studies with human cells and in silico modeling in lieu of additional …

This study presents a novel coupled computational fluid dynamics-discrete element method
(CFD-DEM) model for simulating airflow and inhaled particle dynamics in the nasal cavity …

Intranasal administration of drugs serves as a promising, noninvasive option for the
treatment of various disorders of the central nervous system and upper respiratory tract …