Infections are a major threat to human reproductive health, and infections in pregnancy can
cause prematurity or stillbirth, or can be vertically transmitted to the fetus leading to …

Coronavirus disease 2019 (COVID-19) has swept across the globe causing hundreds of
thousands of deaths, shutting down economies, closing borders and wreaking havoc on an …

Objectives To assess international trends and patterns of prenatal diagnosis of critical
congenital heart defects (CCHDs) and their relation to total and live birth CCHD prevalence …

Objective This study was undertaken to examine the comparative safety of antiseizure
medication (ASM) monotherapy in pregnancy with respect to risk of major congenital …

Although Mendelian genetic disorders are individually rare, they are collectively more
common and contribute disproportionately to pediatric morbidity and mortality. Remarkable …

Abstract Background Congenital heart defects (CHDs) has a multifactorial causation with a
strong genetic component and many environmental triggers. Emerging body of empirical …

Background Improved technology and advances in clinical testing have resulted in
increased detection rates of congenital anomalies during pregnancy, resulting in more …

Objective The purpose of this study was to explore the diagnostic yield and clinical utility of
trio‐based rapid whole exome sequencing (rWES) in pregnancies of fetuses with a wide …

Introduction Congenital anomalies (CAs) are a major cause of infant mortality, childhood
morbidity and long-term disability. Over 130 000 children born in Europe every year will …

Background Congenital anomalies are a leading cause of childhood morbidity, but little is
known about the long-term outcomes. Objective To quantify the burden of disease in …