The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity
of cancer phenotypes and genotypes into a provisional set of underlying principles. As …

Cancer as one of the leading causes of human deaths has always been one of the main
health challenges in the world. Despite recent advances in therapeutic and diagnostic …

Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their …

Melanoma is the deadliest skin cancer. Despite improvements in the understanding of the
molecular mechanisms underlying melanoma biology and in defining new curative …

Stringent transcriptional regulation is crucial for normal cellular biology and organismal
development. Perturbations in the proper regulation of transcription factors can result in …

In contrast to the continuous increase in survival rates for many cancer entities, colorectal
cancer (CRC) and pancreatic cancer are predicted to be ranked among the top 3 cancer …

We, along with others, have shown previously that P21-activated kinase 1 (Pak1) plays a
pivotal role in gastric cancer progression and metastasis. However, whether Pak1 controls …

Tumorigenesis is a complex process that involves a persistent dismantling of cellular
safeguards and checkpoints. These molecular and cellular changes that accumulate over …

Previously, we reported that infection of human macrophages with Mycobacterium
tuberculosis (Mtb) results in massive alterations in the pattern of RNA splicing in the host …

Background Activating transcription factor-2 (ATF2) is a member of the basic leucine zipper
family of DNA-binding proteins, which exhibits both oncogenic and tumor suppression …