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Inflammation in multiple sclerosis: Consequences for remyelination and disease progression
Despite the large number of immunomodulatory or immunosuppressive treatments available
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …
Neurodegeneration and demyelination in multiple sclerosis
Progressive multiple sclerosis (PMS) is an immune-initiated neurodegenerative condition
that lacks effective therapies. Although peripheral immune infiltration is a hallmark of …
that lacks effective therapies. Although peripheral immune infiltration is a hallmark of …
Positron Emission Tomography with [18F]‐DPA‐714 Unveils a Smoldering Component in Most Multiple Sclerosis Lesions which Drives Disease Progression
Objective To determine the prognostic value of persisting neuroinflammation in multiple
sclerosis (MS) lesions, we developed a 18 kDa‐translocator‐protein‐positron emission …
sclerosis (MS) lesions, we developed a 18 kDa‐translocator‐protein‐positron emission …
Choroid plexus enlargement exacerbates white matter hyperintensity growth through glymphatic impairment
Y Li, Y Zhou, W Zhong, X Zhu, Y Chen… - Annals of …, 2023 - Wiley Online Library
Objective Choroid plexus (CP) is a key regulator in cerebrospinal fluid production, but its
contribution to glymphatic clearance function and association with white matter …
contribution to glymphatic clearance function and association with white matter …
Remyelination in the central nervous system
The inability of the mammalian central nervous system (CNS) to undergo spontaneous
regeneration has long been regarded as a central tenet of neurobiology. However, while this …
regeneration has long been regarded as a central tenet of neurobiology. However, while this …
Remyelination protects neurons from DLK-mediated neurodegeneration
Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the
degeneration of neurons and their connections that drives progressive disability in …
degeneration of neurons and their connections that drives progressive disability in …
A fully automatic method to segment choroid plexuses in multiple sclerosis using conventional MRI sequences
Background Choroid plexus (CP) volume has been recently proposed as a proxy for brain
neuroinflammation in multiple sclerosis (MS). Purpose To develop and validate a fast …
neuroinflammation in multiple sclerosis (MS). Purpose To develop and validate a fast …
Time is myelin: early cortical myelin repair prevents atrophy and clinical progression in multiple sclerosis
Cortical myelin loss and repair in multiple sclerosis (MS) have been explored in
neuropathological studies, but the impact of these processes on neurodegeneration and the …
neuropathological studies, but the impact of these processes on neurodegeneration and the …
Longitudinal enlargement of choroid plexus is associated with chronic lesion expansion and neurodegeneration in RRMS patients
Background and Objective: We explored dynamic changes in the choroid plexus (CP) in
patients with relapsing-remitting multiple sclerosis (RRMS) and assessed its relationship …
patients with relapsing-remitting multiple sclerosis (RRMS) and assessed its relationship …
Multiparametric characterization and spatial distribution of different MS lesion phenotypes
BACKGROUND AND PURPOSE: MS lesions exhibit varying degrees of axonal and myelin
damage. A comprehensive description of lesion phenotypes could contribute to an improved …
damage. A comprehensive description of lesion phenotypes could contribute to an improved …