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PI3K isoforms in cell signalling and vesicle trafficking
PI3Ks are a family of lipid kinases that phosphorylate intracellular inositol lipids to regulate
signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided …
signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided …
Phosphoinositides: tiny lipids with giant impact on cell regulation
T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
The emerging mechanisms of isoform-specific PI3K signalling
Abstract Phosphoinositide 3-kinases (PI3Ks) function early in intracellular signal
transduction pathways and affect many biological functions. A further level of complexity …
transduction pathways and affect many biological functions. A further level of complexity …
Classes of phosphoinositide 3-kinases at a glance
ABSTRACT The phosphoinositide 3-kinase (PI3K) family is important to nearly all aspects of
cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially …
cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially …
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
JA Engelman - Nature Reviews Cancer, 2009 - nature.com
There are ample genetic and laboratory studies that suggest the PI3K–Akt pathway is vital to
the growth and survival of cancer cells. Inhibitors targeting this pathway are entering the …
the growth and survival of cancer cells. Inhibitors targeting this pathway are entering the …
Aberrant T cell signaling and subsets in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune
disease, which mainly afflicts women in the reproductive years. A complex interaction of …
disease, which mainly afflicts women in the reproductive years. A complex interaction of …
[HTML][HTML] Efficacy of PI3K inhibitors in advanced breast cancer
Abstract The phosphoinositide 3 (PI3)-kinase/Akt signaling pathway has always been a
focus of interest in breast cancer due to its role in cell growth, cell proliferation, cell migration …
focus of interest in breast cancer due to its role in cell growth, cell proliferation, cell migration …
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
A Carnero, C Blanco-Aparicio, O Renner… - Current cancer drug …, 2008 - ingentaconnect.com
PTEN/PI3K/AKT constitutes an important pathway regulating the signaling of multiple
biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN …
biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN …
[HTML][HTML] A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling
Summary Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug
targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an …
targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an …
Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular …
Targeted therapy with imatinib in chronic myeloid leukemia (CML) prompted a new
treatment paradigm. Unlike CML, chronic lymphocytic leukemia (CLL) lacks an aberrant …
treatment paradigm. Unlike CML, chronic lymphocytic leukemia (CLL) lacks an aberrant …