Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial
damage, but its underlying mechanism and functional consequences are largely unknown …

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …

NLRP3 inflammasome activation is a highly regulated process for controlling secretion of the
potent inflammatory cytokines IL-1β and IL-18 that are essential during bacterial infection …

Heavy metal pollution not only poses a serious threat to both animal growth and public
health, but also to aquatic life. Mitochondria are the first target sites for a variety of heavy …

Mitochondria are cellular organelles with a major role in many cellular processes, including
not only energy production, metabolism, and calcium homeostasis but also regulated cell …

Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad of vital
functions across diverse cellular processes. Dysfunctions within mitochondria serve as …

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-
renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate …