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Metformin: update on mechanisms of action and repurposing potential
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
Human gut microbiome: therapeutic opportunities for metabolic syndrome—hype or hope?
A Horvath, K Zukauskaite, O Hazia… - Endocrinology …, 2024 - Wiley Online Library
Shifts in gut microbiome composition and metabolic disorders are associated with one
another. Clinical studies and experimental data suggest a causal relationship, making the …
another. Clinical studies and experimental data suggest a causal relationship, making the …
Glycosides and flavonoids from the extract of Pueraria thomsonii Benth leaf alleviate type 2 diabetes in high-fat diet plus streptozotocin-induced mice by modulating …
SS Zhang, NN Zhang, S Guo, SJ Liu, YF Hou, S Li… - Food & Function, 2022 - pubs.rsc.org
Twenty glycoside derivatives and nine flavonoids from the leaves of Pueraria (P. thomsonii)
were isolated by column chromatography and characterized by nuclear magnetic resonance …
were isolated by column chromatography and characterized by nuclear magnetic resonance …
Genetically predicted causality of 28 gut microbiome families and type 2 diabetes mellitus risk
K **ang, JJ Zhang, YY Xu, X Zhong, J Ni… - Frontiers in …, 2022 - frontiersin.org
Mounting evidence indicates that gut microbiome may be involved in the pathogenesis of
type 2 diabetes mellitus (T2DM). However, there is no consensus on whether there is a …
type 2 diabetes mellitus (T2DM). However, there is no consensus on whether there is a …
The co-regulation of the gut microbiome and host genes might play essential roles in metformin gastrointestinal intolerance
H Zhang, J Lai, L Zhang, W Zhang, X Liu… - Toxicology and Applied …, 2023 - Elsevier
Metformin is commonly used, but approximately 20% of patients experience gastrointestinal
intolerance, leading to medication discontinuation for unclear reasons and a lack of effective …
intolerance, leading to medication discontinuation for unclear reasons and a lack of effective …
Effects of probiotic Bifidobacterium bifidum G9‐1 on the gastrointestinal symptoms of patients with type 2 diabetes mellitus treated with metformin: An open‐label …
S Hata, H Nakajima, Y Hashimoto… - Journal of Diabetes …, 2022 - Wiley Online Library
ABSTRACT Aims/Introduction Metformin is associated with the risk of gastrointestinal
complications, and probiotic Bifidobacterium bifidum G9‐1 (BBG9‐1) can improve the …
complications, and probiotic Bifidobacterium bifidum G9‐1 (BBG9‐1) can improve the …
Salidroside affects gut microbiota structure in db/db mice by affecting insulin, blood glucose and body weight
Q Zhao, J Shi, S Chen, D Hao, S Wan… - … and Obesity: Targets …, 2022 - Taylor & Francis
Purpose The purpose of this study was to investigate the regulatory effect of salidroside on
the intestinal flora of mice with type 2 diabetes (T2DM) and its protective effect in the body …
the intestinal flora of mice with type 2 diabetes (T2DM) and its protective effect in the body …
Advancements in precision medicine: multi-omics approach for tailored metformin treatment in type 2 diabetes
NR Anwardeen, K Naja, MA Elrayess - Frontiers in Pharmacology, 2024 - frontiersin.org
Metformin has become the frontline treatment in addressing the significant global health
challenge of type 2 diabetes due to its proven effectiveness in lowering blood glucose …
challenge of type 2 diabetes due to its proven effectiveness in lowering blood glucose …
Therapeutic Potential of Vitamin B1 Derivative Benfotiamine From Diabetes to COVID-19
KV Allowitz, JJ Yoo, JR Taylor, OA Baloch… - Future Medicinal …, 2022 - Taylor & Francis
Benfotiamine (S-benzoylthiamine-O-monophosphate), a unique, lipid-soluble derivative of
thiamine, is the most potent allithiamine found in roasted garlic, as well as in other herbs of …
thiamine, is the most potent allithiamine found in roasted garlic, as well as in other herbs of …
Efectos de la metformina en la microbiota intestinal en pacientes con diabetes mellitus tipo 2
HSC Prieto, AAE Jiménez… - … : Revista Científica de la …, 2023 - dialnet.unirioja.es
La metformina es el antidiabético oral más utilizado en la actualidad, se ha demostrado que
modifica las características de la microbiota intestinal de las personas con Diabetes Mellitus …
modifica las características de la microbiota intestinal de las personas con Diabetes Mellitus …