There is increasing interest among functional neurosurgeons in the potential for novel
therapies to impact upon diseases beyond movement disorders and pain. A target of …

Chronic pain is common in patients with neurologic complications of a central nervous
system insult such as stroke. The pain is most commonly musculoskeletal or related to …

Chronic pain causes both physical suffering and comorbid mental symptoms such as
anhedonia. However, the neural circuits and molecular mechanisms underlying these …

Deep brain stimulation (DBS) is a neurosurgical intervention popularised in movement
disorders such as Parkinson's disease, and also reported to improve symptoms of epilepsy …

Pain after stroke is commonly reported but often incompletely managed, which prevents
optimal recovery. This situation occurs in part because of the esoteric nature of poststroke …

Background Deep brain stimulation (DBS) of the anterior cingulate cortex (ACC) is a recent
technique that has shown some promising short-term results in patients with chronic …

The nucleus accumbens (NAc) is a subcortical brain structure known primarily for its roles in
pleasure, reward, and addiction. Despite less focus on the NAc in pain research, it also …

BACKGROUND: Deep brain stimulation (DBS) has shown considerable promise for
relieving nociceptive and neuropathic symptoms of refractory chronic pain. Nevertheless, for …

Chronic pain (pain lasting for> 3 months) decreases patient quality of life and even
occupational abilities. It can be controlled by treatment, but often persists even after …

Parkinson's Disease (PD) is a neurodegenerative disorder that manifests as an impairment
of motor and non-motor abilities due to a loss of dopamine input to deep brain structures …