Maternal exposure to buprenorphine, but not methadone, during pregnancy reduces social play behavior across two generations of offspring

H Nyberg, IL Bogen, E Nygaard, M Achterberg… - …, 2024 - Springer
Objectives Our study employed a translationally relevant animal model to investigate how
maternal (F0) exposure to MOUD during pregnancy affects social behavior in young and …

Prenatal exposure to methadone or buprenorphine alters transcriptional networks associated with synaptic signaling in newborn rats

H Nyberg, IL Bogen, N Duale, JM Andersen - Neuropharmacology, 2025 - Elsevier
While the use of methadone or buprenorphine during pregnancy is beneficial for the
mother's health compared to illicit opioid use, prenatal exposure to these medications may …

Perinatal exposure to methadone or buprenorphine impairs hippocampal-dependent cognition and brain development in juvenile rats

AS Sahid, MJ Bebbington, A Marcus, SJ Baracz… - Progress in Neuro …, 2025 - Elsevier
The opioid crisis continues to escalate, disproportionately affecting women of reproductive
age. Traditionally the first line of treatment for pregnant women with opioid use disorder is …