Many diseases are caused by insufficient expression of mutated genes and would benefit
from increased expression of the corresponding protein. However, in drug development, it …

Dystrophin is essential for muscle health: its sarcolemmal absence causes the fatal, X-linked
condition, Duchenne muscular dystrophy (DMD). However, its normal, spatial organization …

Although they are considered rare disorders, muscular dystrophies have a strong impact on
people's health. Increased disease severity with age, frequently accompanied by the loss of …

Endurance exercise training is beneficial for skeletal muscle health, but it is unclear if this
type of exercise can target or correct the molecular mechanisms of facioscapulohumeral …

Duchenne and Becker muscular dystrophies are allelic X-linked recessive neuromuscular
diseases affecting both skeletal and cardiac muscles. Therefore, owing to their single X …

This perspective article is concerned with the question of how proteomics, which is a core
technique of systems biology that is deeply embedded in the multi-omics field of modern …

The dystrophin‐associated protein complex (DAPC) is a highly organized multiprotein
complex that plays a pivotal role in muscle fiber structure integrity and cell signaling. The …

Duchenne muscular dystrophy is a highly progressive muscle wasting disease of early
childhood and characterized by complex pathophysiological and histopathological changes …

At 2.3 megabases in length, the dystrophin gene is enormous: transcription of a single
mRNA requires approximately 16 h. Principally expressed in skeletal muscle, the dystrophin …

Introduction Duchenne muscular dystrophy (DMD) is a rare X-linked genetic disorder
caused by mutations in the dystrophin gene, leading to an almost complete absence of …