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Transmissibility and transmission of respiratory viruses
Human respiratory virus infections lead to a spectrum of respiratory symptoms and disease
severity, contributing to substantial morbidity, mortality and economic losses worldwide, as …
severity, contributing to substantial morbidity, mortality and economic losses worldwide, as …
Co-evolution of immunity and seasonal influenza viruses
Seasonal influenza viruses cause recurring global epidemics by continually evolving to
escape host immunity. The viral constraints and host immune responses that limit and drive …
escape host immunity. The viral constraints and host immune responses that limit and drive …
A pan-influenza antibody inhibiting neuraminidase via receptor mimicry
Rapidly evolving influenza A viruses (IAVs) and influenza B viruses (IBVs) are major causes
of recurrent lower respiratory tract infections. Current influenza vaccines elicit antibodies …
of recurrent lower respiratory tract infections. Current influenza vaccines elicit antibodies …
Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase
There is growing appreciation for neuraminidase (NA) as an influenza vaccine target;
however, its antigenicity remains poorly characterized. In this study, we isolated three …
however, its antigenicity remains poorly characterized. In this study, we isolated three …
[HTML][HTML] Human anti-N1 monoclonal antibodies elicited by pandemic H1N1 virus infection broadly inhibit HxN1 viruses in vitro and in vivo
Neuraminidase (NA) is one of the two influenza virus surface glycoproteins, and antibodies
that target it are an independent correlate of protection. However, our current understanding …
that target it are an independent correlate of protection. However, our current understanding …
[HTML][HTML] Progress towards the development of a universal influenza vaccine
Influenza viruses are responsible for millions of cases globally and significantly threaten
public health. Since pandemic and zoonotic influenza viruses have emerged in the last 20 …
public health. Since pandemic and zoonotic influenza viruses have emerged in the last 20 …
Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans
Humans are repeatedly exposed to variants of influenza virus throughout their lifetime. As a
result, preexisting influenza-specific memory B cells can dominate the response after …
result, preexisting influenza-specific memory B cells can dominate the response after …
Divergent evolutionary trajectories of influenza B viruses underlie their contemporaneous epidemic activity
Influenza B viruses have circulated in humans for over 80 y, causing a significant disease
burden. Two antigenically distinct lineages (“B/Victoria/2/87-like” and “B/Yamagata/16/88 …
burden. Two antigenically distinct lineages (“B/Victoria/2/87-like” and “B/Yamagata/16/88 …
Cell-based manufacturing technology increases antigenic match of influenza vaccine and results in improved effectiveness
To ensure that vaccination offers the best protection against an infectious disease, sequence
identity between the vaccine and the circulating strain is paramount. During replication of …
identity between the vaccine and the circulating strain is paramount. During replication of …
Anti-neuraminidase immunity in the combat against influenza
Introduction Anti-neuraminidase (NA) immunity correlates with the protection against
influenza virus infection in both human and animal models. The aim of this review is to better …
influenza virus infection in both human and animal models. The aim of this review is to better …