Cancer is one of the leading health hazards and the prominent cause of death in the world.
A number of anticancer agents are currently in clinical practice and used for treatment of …

Multicomponent reactions (MCRs) are powerful synthetic tools in which more than two
starting materials couple with each other to form multi-functionalized compounds in a one …

A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

The combination of heterocycles offers a new opportunity to create novel multicyclic
compounds having improved biological activity. Coumarins are ubiquitous natural …

Naturally occurring coumarins, having wide spectrum of activities such as antioxidant, anti-
inflammatory, anticancer, MAO-B inhibitory and antimicrobial, are frequently used by the …

Nineteen new conjugated compounds were successfully synthesized by a one-flask method
from benzimidazole and coumarin derivatives. A methylenethio linker was used to connect …

A new fluorescent probe (5-[(4-diethylamino-2-hydroxy-benzylidene)-amino]-1H-pyrimidine-
2, 4-dione)(Receptor1) has been synthesized by the Schiff base condensation of 5 …

Histone deacetylases (HDACs) are attractive therapeutic targets for the treatment of cancer
and other diseases. It has four classes (I-IV), among them especially class I isozyme are …

A series of novel coumarin–benzimidazole hybrids, 3-(1H-benzo [d] imidazol-2-yl)-7-
(substituted amino)-2H-chromen-2-one derivatives of biological interest were synthesized …

The increasing interest on new drug discovery is constantly up to date as drugs do not
increase survival adequately against increasing cancer cases worldwide. Based on the …