Thalassemias: from gene to therapy
G De Simone, A Quattrocchi, B Mancini… - Molecular Aspects of …, 2022 - Elsevier
Abstract Thalassemias (α, β, γ, δ, δβ, and εγδβ) are the most common genetic disorders
worldwide and constitute a heterogeneous group of hereditary diseases characterized by …
worldwide and constitute a heterogeneous group of hereditary diseases characterized by …
Cardiac T2* map**: Techniques and clinical applications
Cardiac T2* map** is a noninvasive MRI method that is used to identify myocardial iron
accumulation in several iron storage diseases such as hereditary hemochromatosis, sickle …
accumulation in several iron storage diseases such as hereditary hemochromatosis, sickle …
Monitoring kidney size to interpret MRI‐based assessment of renal oxygenation in acute pathophysiological scenarios
Aim Tissue hypoxia is an early key feature of acute kidney injury. Assessment of renal
oxygenation using magnetic resonance imaging (MRI) markers T2 and T2* enables insights …
oxygenation using magnetic resonance imaging (MRI) markers T2 and T2* enables insights …
Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and hemolysis
The spleen plays a key role in iron homeostasis. It is the largest filter of the blood and
performs iron reuptake from old or damaged erythrocytes. Despite this role, spleen iron …
performs iron reuptake from old or damaged erythrocytes. Despite this role, spleen iron …
[HTML][HTML] Evaluation of thyroid hormones and ferritin level in patients with β-thalassemia
SZ Hussein - Medicine and Pharmacy Reports, 2022 - ncbi.nlm.nih.gov
Methods From August 2019 to January 2020, serum samples were obtained from 90
persons, 30 of whom were healthy, and 60 (46 male and 44 female) with β-thalassemia …
persons, 30 of whom were healthy, and 60 (46 male and 44 female) with β-thalassemia …
[HTML][HTML] Impact of iron overload and iron chelation with deferasirox on outcomes of patients with severe aplastic anemia after allogeneic hematopoietic stem cell …
T Pan, Y Ji, H Liu, B Tang, K Song, X Wan… - … and Cellular Therapy, 2023 - Elsevier
Patients suffering from severe aplastic anemia (SAA) need frequent blood transfusions
during allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, these …
during allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, these …
Pulmonary function in patients with transfusion-dependent thalassemia and its associations with iron overload
In patients with transfusion-dependent thalassemia (TDT), pulmonary function impairment
has been reported but data are conflicting. Moreover, it remains unclear whether pulmonary …
has been reported but data are conflicting. Moreover, it remains unclear whether pulmonary …
Pancreatic MR imaging and endocrine complications in patients with beta-thalassemia: a single-center experience
Iron deposition in various organs can cause endocrine complications in patients with
transfusion-dependent beta-thalassemia. The aim was to investigate the relationship …
transfusion-dependent beta-thalassemia. The aim was to investigate the relationship …
Low Vitamin D Levels Are Associated with Increased Cardiac Iron Uptake in Beta-Thalassemia Major
A Meloni, L Pistoia, C Vassalle, A Spasiano, I Fotzi… - Diagnostics, 2023 - mdpi.com
We evaluated the association of vitamin D and parathormone (PTH) levels with cardiac iron
and function in beta-thalassemia major (β-TM) patients. Two-hundred and seventy-eight TM …
and function in beta-thalassemia major (β-TM) patients. Two-hundred and seventy-eight TM …
Body iron status of children and adolescents with transfusion dependent β-thalassaemia: trends of serum ferritin and associations of optimal body iron control
Objective This cross sectional study aims to describe the body iron status, trends of serum
ferritin and associations of optimal body iron control in patients aged below 16 years with …
ferritin and associations of optimal body iron control in patients aged below 16 years with …