Cell culture is a widely used in vitro tool for improving our understanding of cell biology,
tissue morphology, and mechanisms of diseases, drug action, protein production and the …

The liver is the largest internal organ of the body with complex microarchitecture and
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Moving from cell monolayers to three-dimensional (3D) cultures is motivated by the need to
work with cellular models that mimic the functions of living tissues. Essential cellular …

Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic fatty liver (NAFL) and non-
alcoholic steatohepatitis (NASH), represents the hepatic manifestation of obesity and …

Liver regeneration is a well-orchestrated process that is typically studied in animal models.
Although previous animal studies have offered many insights into liver regeneration, human …

Bioprinting is an emergent technology that has already demonstrated the capacity to create
complex and/or vascularized multicellular structures with defined and organized …

The liver is an organ with critical importance for drug treatment as the disposition and
response to a given drug is often determined by its hepatic metabolism. Patient-specific …

Within the liver, non-parenchymal cells (NPCs) are critically involved in the regulation of
hepatocyte polarization and maintenance of metabolic function. We here report the …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …