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Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease
Cell death is a vital process that occurs in billions of cells in the human body every day. This
process helps maintain tissue homeostasis, supports recovery from acute injury, deals with …
process helps maintain tissue homeostasis, supports recovery from acute injury, deals with …
Molecular crosstalk between apoptosis, necroptosis, and survival signaling
Our current knowledge of the molecular mechanisms regulating the signaling pathways
leading to cell survival, cell death, and inflammation has shed light on the tight mutual …
leading to cell survival, cell death, and inflammation has shed light on the tight mutual …
Pathogenic gut flora in patients with chronic heart failure
E Pasini, R Aquilani, C Testa, P Baiardi, S Angioletti… - JACC: Heart Failure, 2016 - jacc.org
Objectives: The goal of this study was to measure the presence of pathogenic gut flora and
intestinal permeability (IP) and their correlations with disease severity, venous blood …
intestinal permeability (IP) and their correlations with disease severity, venous blood …
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation
Cell death signalling pathways contribute to tissue homeostasis and provide innate
protection from infection. Adaptor proteins such as receptor-interacting serine/threonine …
protection from infection. Adaptor proteins such as receptor-interacting serine/threonine …
Sex, age, and bacteria: how the intestinal microbiota is modulated in a protandrous hermaphrodite fish
Intestinal microbiota is key for many host functions, such as digestion, nutrient metabolism,
disease resistance, and immune function. With the growth of the aquaculture industry, there …
disease resistance, and immune function. With the growth of the aquaculture industry, there …
Cellular Aspects of Shigella Pathogenesis: Focus on the Manipulation of Host Cell Processes
Shigella is a Gram-negative bacterium that is responsible for shigellosis. Over the years, the
study of Shigella has provided a greater understanding of how the host responds to bacterial …
study of Shigella has provided a greater understanding of how the host responds to bacterial …
SseK1 and SseK3 type III secretion system effectors inhibit NF-κB signaling and necroptotic cell death in Salmonella-infected macrophages
RA Günster, SA Matthews, DW Holden… - Infection and …, 2017 - journals.asm.org
Within host cells such as macrophages, Salmonella enterica translocates virulence (effector)
proteins across its vacuolar membrane via the SPI-2 type III secretion system. Previously, it …
proteins across its vacuolar membrane via the SPI-2 type III secretion system. Previously, it …
Microbial functional amyloids serve diverse purposes for structure, adhesion and defence
The functional amyloid state of proteins has in recent years garnered much attention for its
role in serving crucial and diverse biological roles. Amyloid is a protein fold characterised by …
role in serving crucial and diverse biological roles. Amyloid is a protein fold characterised by …
Citrobacter rodentium subverts ATP flux and cholesterol homeostasis in intestinal epithelial cells in vivo
The intestinal epithelial cells (IECs) that line the gut form a robust line of defense against
ingested pathogens. We investigated the impact of infection with the enteric pathogen …
ingested pathogens. We investigated the impact of infection with the enteric pathogen …
Characteristics of the gut microbiota colonization, inflammatory profile, and plasma metabolome in intrauterine growth restricted piglets during the first 12 hours after …
S Huang, N Li, C Liu, T Li, W Wang, L Jiang, Z Li… - Journal of …, 2019 - Springer
Intrauterine growth restriction (IUGR) predisposes newborns to inflammatory and metabolic
disturbance. Disequilibrium of gut microbiota in early life has been implicated in the …
disturbance. Disequilibrium of gut microbiota in early life has been implicated in the …