Cell-derived extracellular matrix for tissue engineering and regenerative medicine

M Assunção, D Dehghan-Baniani, CHK Yiu… - … in bioengineering and …, 2020 - frontiersin.org
Cell-derived extracellular matrices (CD-ECMs) captured increasing attention since the first
studies in the 1980s. The biological resemblance of CD-ECMs to their in vivo counterparts …

Decellularized Extracellular Matrix as an In Vitro Model to Study the Comprehensive Roles of the ECM in Stem Cell Differentiation

T Hoshiba, G Chen, C Endo, H Maruyama… - Stem cells …, 2016 - Wiley Online Library
Stem cells are a promising cell source for regenerative medicine. Stem cell differentiation
must be regulated for applications in regenerative medicine. Stem cells are surrounded by …

Perfusion-decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering

SK Goh, S Bertera, P Olsen, JE Candiello, W Halfter… - Biomaterials, 2013 - Elsevier
Approximately 285 million people worldwide suffer from diabetes, with insulin
supplementation as the most common treatment measure. Regenerative medicine …

Cell-derived matrices for tissue engineering and regenerative medicine applications

LE Fitzpatrick, TC McDevitt - Biomaterials science, 2015 - pubs.rsc.org
The development and application of decellularized extracellular matrices (ECM) has grown
rapidly in the fields of cell biology, tissue engineering and regenerative medicine in recent …

Bioengineering thymus organoids to restore thymic function and induce donor-specific immune tolerance to allografts

Y Fan, A Tajima, SK Goh, X Geng, G Gualtierotti… - Molecular Therapy, 2015 - cell.com
One of the major obstacles in organ transplantation is to establish immune tolerance of
allografts. Although immunosuppressive drugs can prevent graft rejection to a certain …

Nanofat cell aggregates: a nearly constitutive stromal cell inoculum for regenerative site-specific therapies

B Sesé, JM Sanmartín, B Ortega… - Plastic and …, 2019 - journals.lww.com
Background: Recent technology developed by Tulip Medical Products allows clinicians to
mechanically disaggregate fat tissue into small fat particles known as nanofat. The present …

Vimentin protects differentiating stem cells from stress

S Pattabiraman, GK Azad, T Amen, S Brielle, JE Park… - Scientific Reports, 2020 - nature.com
Vimentin is one of the first cytoplasmic intermediate filaments to be expressed in mammalian
cells during embryogenesis, but its role in cellular fitness has long been a mystery. Vimentin …

Engineering stem cell-derived extracellular matrices: decellularization, characterization, and biological function

S Sart, R Jeske, X Chen, T Ma, Y Li - Tissue Engineering Part B …, 2020 - liebertpub.com
Stem cells, including mesenchymal stem cells and pluripotent stem cells, have attracted
considerable attention in tissue engineering and regenerative medicine primarily because of …

Decellularized extracellular matrix mediates tissue construction and regeneration

C Liu, M Pei, Q Li, Y Zhang - Frontiers of medicine, 2022 - Springer
Contributing to organ formation and tissue regeneration, extracellular matrix (ECM)
constituents provide tissue with three-dimensional (3D) structural integrity and cellular …

Engineering three-dimensional stem cell morphogenesis for the development of tissue models and scalable regenerative therapeutics

MA Kinney, TA Hookway, Y Wang… - Annals of biomedical …, 2014 - Springer
The physiochemical stem cell microenvironment regulates the delicate balance between self-
renewal and differentiation. The three-dimensional assembly of stem cells facilitates cellular …