A quinquennial review on recent advancements and developments in search of anti-malarial agents
TM Dhameliya, D Kathuria, TM Patel… - Current Topics in …, 2023 - benthamdirect.com
Malaria has been a major parasitic disease in tropical and subtropical regions and is
estimated to kill between one and two million people (mainly children) every year. Novel anti …
estimated to kill between one and two million people (mainly children) every year. Novel anti …
Sustainable approaches towards the synthesis of quinoxalines: An update
Heterocycles and their derivatives have been inspiring medicinal chemists to device novel,
greener and efficient ways to synthesized them as the majority of drugs available in the …
greener and efficient ways to synthesized them as the majority of drugs available in the …
[HTML][HTML] Integrated network pharmacology and in-silico approaches to decipher the pharmacological mechanism of Selaginella tamariscina in the treatment of non …
Background and purpose Non-small cell lung cancer (NSCLC) is a major pathological type
of lung cancer and accounts for more than 80% of all cases. In healthcare management, it is …
of lung cancer and accounts for more than 80% of all cases. In healthcare management, it is …
Probing the molecular mechanisms of α-synuclein inhibitors unveils promising natural candidates through machine-learning QSAR, pharmacophore modeling, and …
Parkinson's disease is characterized by a multifactorial nature that is linked to different
pathways. Among them, the abnormal deposition and accumulation of α-synuclein fibrils is …
pathways. Among them, the abnormal deposition and accumulation of α-synuclein fibrils is …
In silico screening, ADMET analysis and MD simulations of phytochemicals of Onosma bracteata Wall. as SARS CoV-2 inhibitors
Being attracted with their cardiotonic, antidiabetic, cough relieving activity, treatment of fever,
absorbent, anti-asthmatic, etc. activities reported in ancient Ayurvedic literature …
absorbent, anti-asthmatic, etc. activities reported in ancient Ayurvedic literature …
In silico identification of five binding sites on the SARS-CoV-2 spike protein and selection of seven ligands for such sites
DF de Oliveira - Journal of Biomolecular Structure and Dynamics, 2024 - Taylor & Francis
To contribute to the development of products capable of complexing with the SARS-CoV-2
spike protein, and thus preventing the virus from entering the host cell, this work aimed at …
spike protein, and thus preventing the virus from entering the host cell, this work aimed at …
Determinants for Sugar-Induced modulation of thermodynamic stability of lysozyme
The current study focuses on the experimental evidence to describe the molecular
mechanism by which the sugars modulate the thermodynamic stability of hen egg-white …
mechanism by which the sugars modulate the thermodynamic stability of hen egg-white …
Structure based drug designing approaches in SARS-CoV-2 spike inhibitor design
A Shanmugam, A Venkattappan… - Current Topics in …, 2022 - ingentaconnect.com
The COVID-19 outbreak and the pandemic situation have hastened the research community
to design a novel drug and vaccine against its causative organism, the SARS-CoV-2. The …
to design a novel drug and vaccine against its causative organism, the SARS-CoV-2. The …
[HTML][HTML] Insights into the Gene Expression Profile of Classical Hodgkin Lymphoma: A Study towards Discovery of Novel Therapeutic Targets
AA Aloliqi - Molecules, 2024 - mdpi.com
Classical Hodgkin lymphoma (cHL) is a common B-cell cancer and a significant health
concern, especially in Western and Asian countries. Despite the effectiveness of …
concern, especially in Western and Asian countries. Despite the effectiveness of …
The Malaria Box molecules: a source for targeting the RBD and NTD cryptic pocket of the spike glycoprotein in SARS-CoV-2
Abstract Context SARS-CoV-2, responsible for COVID-19, has led to over 500 million
infections and more than 6 million deaths globally. There have been limited effective …
infections and more than 6 million deaths globally. There have been limited effective …