Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …

Adipose tissues in the hypodermis, the crucial stem cell reservoir in the skin and the
endocrine organ for the maintenance of skin homeostasis undergo significant changes …

Cartilage oligomeric matrix protein (COMP) is an extracellular matrix (ECM) glycoprotein that
is critical for collagen assembly and ECM stability. Mutations of COMP cause endoplasmic …

Highlights•Exosomes are involved in tumor microenvironment remodeling.•Tumor cell
heterogeneity and metabolic reprogramming are mediated by exosomes.•Exosomes aid in …

Diabesity is a condition where an individual has both diabetes and obesity, which can lead
to severe complications including cardiovascular disease, a leading cause of mortality …

Background Breast cancer is the leading female cancer type and the cause of cancer-
related mortality worldwide. Adipocytes possess important functions of energy supply …

Cancer stem cells (CSCs) are a highly tumorigenic subpopulation of the cancer cells within
a tumor that drive tumor initiation, progression, and therapy resistance. In general, stem cell …

Adipose tissue is comprised of a heterogeneous population of cells that co-operate to
perform diverse physiological roles including endocrine-related functions. The endocrine …

Adipose tissue and its diverse cell types constitute one of the largest endocrine organs. With
multiple depot locations, adipose tissue plays an important regulatory role through paracrine …

Epithelial-mesenchymal transition (EMT) as a trans-differentiation program and a key
process in tumor progression is linked positively with increased expansion of cancer stem …