Objective Research and clinical interest in irritability have been on the rise in recent years.
Yet several questions remain about the status of irritability in psychiatry, including whether …

Although irritability is among the most common reasons that children and adolescents are
brought for psychiatric care, there are few effective treatments. Developmentally sensitive …

This selective review provides a model of the neurobiology of impulsive aggression from a
cognitive neuroscience perspective. It is argued that prototypical cases of impulsive …

Irritability is a common and impairing clinical presentation in children and adolescents.
Despite its significant public health impact, irritability remains an elusive construct. Chronic …

In preparation for the World Health Organization's development of the Eleventh Revision of
the International Classification of Diseases and Related Health Problems (ICD-11) chapter …

Irritability, defined as an increased propensity to exhibit increased anger relative to one's
peers, is a common clinical problem in youth. Irritability can be conceptualized as aberrant …

Irritability is a symptom of 15 disorders in the DSM-5 and is included in Mood Disorders,
Addictive Disorders, Personality Disorders, and more (American Psychiatric Association …

Objective: Irritability in disruptive mood dysregulation disorder (DMDD) may be associated
with a biased tendency to judge ambiguous facial expressions as angry. We conducted …

Background Individuals with intermittent explosive disorder (IED) were previously found to
exhibit amygdala hyperactivation and relatively reduced orbital medial prefrontal cortex …

Importance Psychiatric comorbidity complicates clinical care and confounds efforts to
elucidate the pathophysiology of commonly occurring symptoms in youths. To our …