Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …

Nature endows life with a wide variety of sophisticated, synergistic, and highly functional
protein assemblies. Following Nature's inspiration to assemble protein building blocks into …

Hydrogen (H)-bonds potentiate diverse cellular functions by facilitating molecular
interactions. The mechanism and the extent to which H-bonds regulate molecular …

Various conventional reactions in polymer chemistry have been translated to the
supramolecular domain, yet it has remained challenging to devise living supramolecular …

Though emerging evidence indicates that the pathogenesis of Parkinson's disease is
strongly correlated to the accumulation, and transmission, of α-synuclein (α-syn) aggregates …

Self-assembled peptide nanostructures have been increasingly exploited as functional
materials for applications in biomedicine and energy. The emergent properties of these …

The construction of bioactive peptides using β-amino acid-containing sequence patterns is a
very promising strategy to obtain analogues that exhibit properties of high interest for …

The normally soluble TAR DNA-binding protein 43 (TDP-43) is found aggregated both in
reversible stress granules and in irreversible pathogenic amyloid. In TDP-43, the low …

Proteins have evolved as a variable platform that provides access to molecules with diverse
shapes, sizes and functions. These features have inspired chemists for decades to seek …

Amyloid formation is implicated in more than 20 human diseases, yet the mechanism by
which fibrils form is not well understood. We use 2D infrared spectroscopy and isotope …