Mammalian embryonic development is a tightly regulated process that, from a single zygote,
produces a large number of cell types with hugely divergent functions. Distinct cellular …

Formation of skeletal muscle fibers (myogenesis) during development and after tissue injury
in the adult constitutes an excellent paradigm to investigate the mechanisms whereby …

DNA methylation is important for the epigenetic regulation of gene expression and plays a
critical role in mammalian development. However, the dynamic regulation of genome-wide …

Abstract Changes in potential regulatory elements are thought to be key drivers of
phenotypic divergence. However, identifying changes to regulatory elements that underlie …

DNA methylation is an essential epigenetic modification for mammalian development and is
crucial for the establishment and maintenance of cellular identity. Traditionally, DNA …

Skeletal muscle development and regeneration is governed by the combined action of Myf5,
MyoD, Mrf4 and MyoG, also known as the myogenic regulatory factors (MRFs). These …

Skeletal muscle regeneration is initiated by satellite cells, a population of adult stem cells
that reside in the muscle tissue. The ability of satellite cells to self-renew and to differentiate …

DNA methylation is a key epigenetic mark that is critical for gene regulation in multicellular
eukaryotes. Although various human cell types may have the same genome, these cells …

The generation of myotubes from fibroblasts upon forced MyoD expression is a classic
example of transcription factor-induced reprogramming. We recently discovered that …

Simple Summary Muscle plasticity is defined as the ability of the muscle to respond to
changes in environmental conditions. Muscle plasticity is exceptionally dynamic in fish; this …