Sarcopenia: aging-related loss of muscle mass and function

L Larsson, H Degens, M Li, L Salviati… - Physiological …, 2019 - journals.physiology.org
Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

[HTML][HTML] Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis

A Sierra, JM Encinas, JJP Deudero, JH Chancey… - Cell stem cell, 2010 - cell.com
In the adult hippocampus, neuroprogenitor cells in the subgranular zone (SGZ) of the
dentate gyrus give rise to newborn neuroblasts. However, only a small subset of these cells …

The cell biology of neurogenesis

M Götz, WB Huttner - Nature reviews Molecular cell biology, 2005 - nature.com
During the development of the mammalian central nervous system, neural stem cells and
their derivative progenitor cells generate neurons by asymmetric and symmetric divisions …

Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells

SJ Pfau, UH Langen, TM Fisher, I Prakash… - Nature …, 2024 - nature.com
The blood–brain barrier (BBB) protects the brain and maintains neuronal homeostasis. BBB
properties can vary between brain regions to support regional functions, yet how BBB …

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

DS Leeman, K Hebestreit, T Ruetz, AE Webb, A McKay… - Science, 2018 - science.org
In the adult brain, the neural stem cell (NSC) pool comprises quiescent and activated
populations with distinct roles. Transcriptomic analysis revealed that quiescent and activated …

Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing

H Hochgerner, A Zeisel, P Lönnerberg… - Nature …, 2018 - nature.com
The dentate gyrus of the hippocampus is a brain region in which neurogenesis persists into
adulthood; however, the relationship between developmental and adult dentate gyrus …

Bioinspired neuron-like electronics

X Yang, T Zhou, TJ Zwang, G Hong, Y Zhao… - Nature materials, 2019 - nature.com
As an important application of functional biomaterials, neural probes have contributed
substantially to studying the brain. Bioinspired and biomimetic strategies have begun to be …

Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche

P Codega, V Silva-Vargas, A Paul… - Neuron, 2014 - cell.com
Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity
has been elusive. Here, we prospectively isolate GFAP+ CD133+(quiescent neural stem …