The conformational states of the HIV-1 envelope glycoproteins
During HIV-1 entry into target cells, binding of the virus to host receptors, CD4 and
CCR5/CXCR4, triggers serial conformational changes in the envelope glycoprotein (Env) …
CCR5/CXCR4, triggers serial conformational changes in the envelope glycoprotein (Env) …
The HIV Env glycoprotein conformational states on cells and viruses
The HIV Env glycoprotein is the surface glycoprotein responsible for viral entry into CD4+
immune cells. During infection, Env also serves as a primary target for antibody responses …
immune cells. During infection, Env also serves as a primary target for antibody responses …
Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates
The development of an effective AIDS vaccine remains a challenge. Nucleoside-modified
mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of …
mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of …
Characterization of HIV-1 nucleoside-modified mRNA vaccines in rabbits and rhesus macaques
Despite the enormous effort in the development of effective vaccines against HIV-1, no
vaccine candidate has elicited broadly neutralizing antibodies in humans. Thus, generation …
vaccine candidate has elicited broadly neutralizing antibodies in humans. Thus, generation …
An asymmetric opening of HIV-1 envelope mediates antibody-dependent cellular cytotoxicity
The HIV-1 envelope glycoprotein (Env)(gp120-gp41) 3 is the target for neutralizing
antibodies and antibody-dependent cellular cytotoxicity (ADCC). HIV-1 Env is flexible …
antibodies and antibody-dependent cellular cytotoxicity (ADCC). HIV-1 Env is flexible …
Epistatic pathways can drive HIV-1 escape from integrase strand transfer inhibitors
People living with human immunodeficiency virus (HIV) receiving integrase strand transfer
inhibitors (INSTIs) have been reported to experience virological failure in the absence of …
inhibitors (INSTIs) have been reported to experience virological failure in the absence of …
Asymmetric conformations of cleaved HIV-1 envelope glycoprotein trimers in styrene-maleic acid lipid nanoparticles
During virus entry, the pretriggered human immunodeficiency virus (HIV-1) envelope
glycoprotein (Env) trimer initially transits into a default intermediate state (DIS) that remains …
glycoprotein (Env) trimer initially transits into a default intermediate state (DIS) that remains …
Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein …
The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer mediates
entry into host cells by binding receptors, CD4 and CCR5/CXCR4, and fusing the viral and …
entry into host cells by binding receptors, CD4 and CCR5/CXCR4, and fusing the viral and …
Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements
The trimeric HIV-1 Envelope protein (Env) mediates viral-host cell fusion via a network of
conformational transitions, with allosteric elements in each protomer orchestrating host …
conformational transitions, with allosteric elements in each protomer orchestrating host …
The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions
The entry of HIV-1 into target cells is mediated by the viral envelope glycoproteins (Env).
Binding to the CD4 receptor triggers a cascade of conformational changes in distant …
Binding to the CD4 receptor triggers a cascade of conformational changes in distant …