The importance of water and hydraulic pressure in cell dynamics
All mammalian cells live in the aqueous medium, yet for many cell biologists, water is a
passive arena in which proteins are the leading players that carry out essential biological …
passive arena in which proteins are the leading players that carry out essential biological …
Exploring cell and tissue mechanics with optical tweezers
Cellular and tissue biosystems emerge from the assembly of their constituent molecules and
obtain a set of specific material properties. To measure these properties and understand …
obtain a set of specific material properties. To measure these properties and understand …
Osmotic gradients in epithelial acini increase mechanical tension across E-cadherin, drive morphogenesis, and maintain homeostasis
Epithelial cells spontaneously form acini (also known as cysts or spheroids) with a single,
fluid-filled central lumen when grown in 3D matrices. The size of the lumen is dependent on …
fluid-filled central lumen when grown in 3D matrices. The size of the lumen is dependent on …
The osteoclast cytoskeleton–current understanding and therapeutic perspectives for osteoporosis
A Blangy, G Bompard, D Guerit, P Marie… - Journal of cell …, 2020 - journals.biologists.com
Osteoclasts are giant multinucleated myeloid cells specialized for bone resorption, which is
essential for the preservation of bone health throughout life. The activity of osteoclasts relies …
essential for the preservation of bone health throughout life. The activity of osteoclasts relies …
The desmosome-intermediate filament system facilitates mechanotransduction at adherens junctions for epithelial homeostasis
Epithelial homeostasis can be critically influenced by how cells respond to mechanical
forces, both local changes in force balance between cells and altered tissue-level forces. 1 …
forces, both local changes in force balance between cells and altered tissue-level forces. 1 …
Lumen expansion is initially driven by apical actin polymerization followed by osmotic pressure in a human epiblast model
Post-implantation, the pluripotent epiblast in a human embryo forms a central lumen, paving
the way for gastrulation. Osmotic pressure gradients are considered the drivers of lumen …
the way for gastrulation. Osmotic pressure gradients are considered the drivers of lumen …
Integration of luminal pressure and signalling in tissue self-organization
CJ Chan, T Hiiragi - Development, 2020 - journals.biologists.com
Many developmental processes involve the emergence of intercellular fluid-filled lumina.
This process of luminogenesis results in a build up of hydrostatic pressure and signalling …
This process of luminogenesis results in a build up of hydrostatic pressure and signalling …
The complex three-dimensional organization of epithelial tissues
Understanding the cellular organization of tissues is key to developmental biology. In order
to deal with this complex problem, researchers have taken advantage of reductionist …
to deal with this complex problem, researchers have taken advantage of reductionist …
Pneumatic equiaxial compression device for mechanical manipulation of epithelial cell packing and physiology
It is well established that mechanical cues, eg, tensile-compressive-or shear forces, are
important co-regulators of cell and tissue physiology. To understand the mechanistic effects …
important co-regulators of cell and tissue physiology. To understand the mechanistic effects …
Rigidity in mechanical biological networks
ML Manning - Current Biology, 2024 - cell.com
Multicellular organisms generate complex morphologies required for their function.
Organisms control these morphologies by tuning active forces and by altering the emergent …
Organisms control these morphologies by tuning active forces and by altering the emergent …