Genome-wide association studies (GWASs) provide an unprecedented opportunity to
examine, on a large scale, the association of common genetic variants with complex …

Diabetes mellitus (DM) is one of the principal manifestations of metabolic syndrome and its
prevalence with modern lifestyle is increasing incessantly. Chronic hyperglycemia can …

Objective Although glucagon-secreting α-cells and insulin-secreting β-cells have opposing
functions in regulating plasma glucose levels, the two cell types share a common …

Type 2 diabetes, fuelled by the obesity epidemic, is an escalating worldwide cause of
personal hardship and public cost. Diabetes incidence increases with age, and many …

Diabetes mellitus (DM) is a group of metabolic diseases related to the dysfunction of insulin,
causing hyperglycaemia and life-threatening complications. Current early screening and …

Decreased number and function of beta cells are a key aspect of diabetes mellitus
(diabetes), a disease that remains an onerous global health problem. Means of restoring …

Objectives Genome-wide association studies have reported that DNA polymorphisms at the
CDKN2A locus modulate fasting glucose in human and contribute to type 2 diabetes (T2D) …

The loss of pancreatic β-cell identity has emerged as an important feature of type 2 diabetes
development, but the molecular mechanisms are still elusive. Here, we explore the cell …

Abstract Indigenous inhabitants of South America and other areas have been using stevia
as a traditional medicine for years, but its impact on cell signaling pathways has not been …

The INK4-ARF locus includes the CDKN2B and CDKN2A genes and is functionally relevant
in the regulation of both cell proliferation and senescence. Studies have reported …