X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Although often located at a distance from their target gene promoters, enhancers are the
primary genomic determinants of temporal and spatial transcriptional specificity in …

Super-enhancers (SEs) are cell-specific DNA cis-regulatory elements that can supervise the
transcriptional regulation processes of downstream genes. SEdb 2.0 (http://www. licpathway …

Abstract Motivation Three-dimensional (3D) genome organization is of vital importance in
gene regulation and disease mechanisms. Previous studies have shown that CTCF …

Background Individuals affected with autism often suffer additional co-morbidities such as
intellectual disability. The genes contributing to autism cluster on a relatively limited number …

Background B-type lamins are critical nuclear envelope proteins that interact with the three-
dimensional genomic architecture. However, identifying the direct roles of B-lamins on …

Early in development, placental and marsupial mammals harbouring at least two X
chromosomes per nucleus are faced with a choice that affects the rest of their lives: which of …

Complex functioning of the genome in the cell nucleus is controlled at different levels:(a) the
DNA base sequence containing all relevant inherited information;(b) epigenetic pathways …

Background Bromodomain and extraterminal proteins (BETs) are more than just epigenetic
regulators of transcription. Here we highlight a new role for the BET protein BRD4 in the …