Carbapenems are considered as last-resort antibiotics for the treatment of infections caused
by multidrug-resistant Gram-negative bacteria. With the increasing use of carbapenems in …

The dissemination of carbapenem-resistant Gram-negative bacilli (CRGNB) is a global
public health issue. CRGNB isolates are usually extensively drug-resistant or pandrug …

Therapy of invasive infections due to multidrug-resistant Enterobacteriaceae (MDR-E) is
challenging, and some of the few active drugs are not available in many countries. For …

Scope These ESCMID guidelines address the targeted antibiotic treatment of third-
generation cephalosporin-resistant Enterobacterales (3GCephRE) and carbapenem …

Abstract Background Bloodstream infections (BSIs) by Klebsiella pneumoniae
carbapenemase (KPC)-producing Klebsiella pneumoniae (Kp) are associated with high …

Background Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-
KP) has become one of the most important contemporary pathogens, especially in endemic …

ABSTRACT From January 2019 to April 2020, 32 KPC-producing, ceftazidime-avibactam
(CZA)-resistant Klebsiella pneumoniae strains were isolated in a university hospital in …

Background The management and indication of empiric treatment in Klebsiella pneumoniae
carbapenemase–producing K. pneumoniae (KPC-Kp)–colonized patients should be …

Resistance to colistin, a polypeptide drug used as an agent of last resort for the treatment of
infections caused by multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram …

Background Among MDR bacteria, carbapenem-resistant Acinetobacter baumannii (CRAB)
is a major concern due to the limited therapeutic options. During the COVID-19 pandemic, a …