Advances in therapies to treat neonatal hypoxic-ischemic encephalopathy

AK Ranjan, A Gulati - Journal of clinical medicine, 2023 - mdpi.com
Neonatal hypoxic-ischemic encephalopathy (HIE) is a condition that results in brain damage
in newborns due to insufficient blood and oxygen supply during or after birth. HIE is a major …

White matter injury and neurodevelopmental disabilities: A cross-disease (dis) connection

E Cainelli, F Arrigoni, L Vedovelli - Progress in neurobiology, 2020 - Elsevier
White matter (WM) injury, once known primarily in preterm newborns, is emerging in its non-
focal (diffused), non-necrotic form as a critical component of subtle brain injuries in many …

Mild hypoxic-ischemic encephalopathy (HIE): timing and pattern of MRI brain injury

Y Li, JL Wisnowski, L Chalak, AM Mathur… - Pediatric …, 2022 - nature.com
Background Mild hypoxic-ischemic encephalopathy (HIE) is increasingly recognized as a
risk factor for neonatal brain injury. We examined the timing and pattern of brain injury in …

[PDF][PDF] Advances in understanding the mechanism of transitional neonatal hypoglycemia and implications for management

DL Stanescu, CA Stanley - Clinics in perinatology, 2022 - Elsevier
100 words). Our lack of basic knowledge about the basic mechanisms of transitional
hypoglycemia and other forms of hypoglycemia in newborns underlies the on-going …

Impact of hypoxia-ischemia on neurogenesis and structural and functional outcomes in a mild–moderate neonatal hypoxia-ischemia brain injury model

A Ehlting, M Zweyer, E Maes, Y Schleehuber, H Doshi… - Life, 2022 - mdpi.com
Hypoxic-ischemic encephalopathy (HIE) is a common type of brain injury caused by a lack of
oxygen and blood flow to the brain during the perinatal period. The incidence of HIE is …

Association between early EEG background and outcomes in infants with mild HIE undergoing therapeutic hypothermia

N Natarajan, G Benedetti, FA Perez, TR Wood… - Pediatric Neurology, 2022 - Elsevier
Background Hypoxic-ischemic encephalopathy (HIE) occurs in 1-4: 1000 live births.
Although neonates with moderate-severe HIE have been studied over several decades …

A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR

MM Ross, S Cherkerzian, ND Mikulis, D Turner… - Scientific reports, 2021 - nature.com
Animal studies have demonstrated the therapeutic potential of polyphenol-rich pomegranate
juice. We recently reported altered white matter microstructure and functional connectivity in …

New horizons in mild hypoxic-ischemic encephalopathy: a standardized algorithm to move past conundrum of care

L Chalak - Clinics in Perinatology, 2022 - perinatology.theclinics.com
Worldwide, hypoxic-ischemic encephalopathy (HIE) affects 2 million infants annually 1; it
presents clinically as neonatal encephalopathy (NE) is difficult to classify immediately after …

Is it time for a randomized controlled trial of hypothermia for mild hypoxic-ischemic encephalopathy?

S Chawla, SV Bates, S Shankaran - The Journal of pediatrics, 2020 - jpeds.com
The time is right to perform a randomized controlled trial (RCT) of neuroprotection for
neonates with mild hypoxic-ischemic encephalopathy (HIE). According to published reports …

The general movements assessment in neonates with hypoxic ischemic encephalopathy

NR Pouppirt, V Martin… - Journal of child …, 2021 - journals.sagepub.com
Background: Clinical measures after birth and studies such as electroencephalogram (EEG)
and brain imaging do not fully predict neurodevelopmental outcomes of infants with hypoxic …