Nanocarrier-based drug delivery systems hold impressive promise for biomedical
application because of their excellent water dispersibility, prolonged blood circulation time …

The considerable development of carrier-free nanodrugs has been achieved due to their
high drug-loading capability, simple preparation method, and offering “all-in-one” functional …

Covalent modification of therapeutic compounds is a clinically proven strategy to devise
prodrugs with enhanced treatment efficacies. This prodrug strategy relies on the modified …

Clinical applications of many anti-cancer drugs are restricted due to their hydrophobic
nature, requiring use of harmful organic solvents for administration, and poor selectivity and …

Covalent organic frameworks (COFs) and their derivatives represent an emerging class of
crystalline porous materials with broad potential applications. However, the biomedical …

We review drug conjugates combining a tumor-selective moiety with a cytotoxic agent as
cancer treatments. Currently, antibody-drug conjugates (ADCs) are the most common drug …

A widely established prodrug strategy can effectively optimize the unappealing properties of
therapeutic agents in cancer treatment. Among them, lipidic prodrugs extremely uplift the …

Unsaturated fatty acids (UFAs), with the distinct advantages of good biocompatibility and
innate tumor-targeting effect, have been widely investigated for the rational design of …

Many drug molecules that are currently in the market suffer from short half-life, poor
absorption, low specificity, rapid degradation, and resistance development. The design and …

Nanomedicines suffer from poor drug loading and uncontrolled 'burst release'after
administration. Combining prodrug strategies with nanostructured carriers can help to …