3′-end processing of eukaryotic mRNA: machinery, regulation, and impact on gene expression
V Boreikaitė, LA Passmore - Annual review of biochemistry, 2023 - annualreviews.org
Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …
transcript. This process is mediated by a number of protein factors that cleave the pre …
How cells get the message: dynamic assembly and function of mRNA–protein complexes
Abstract mRNA is packaged into ribonucleoprotein particles called mRNPs. A multitude of
RNA-binding proteins as well as a host of associated proteins participate in the fate of …
RNA-binding proteins as well as a host of associated proteins participate in the fate of …
Control of mammalian gene expression by selective mRNA export
VO Wickramasinghe, RA Laskey - Nature reviews Molecular cell biology, 2015 - nature.com
Nuclear export of mRNAs is a crucial step in the regulation of gene expression, linking
transcription in the nucleus to translation in the cytoplasm. Although important components …
transcription in the nucleus to translation in the cytoplasm. Although important components …
The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes
Background The SR proteins comprise a family of essential, structurally related RNA binding
proteins. The complexity of their RNA targets and specificity of RNA recognition in vivo is not …
proteins. The complexity of their RNA targets and specificity of RNA recognition in vivo is not …
Replication-dependent histone biosynthesis is coupled to cell-cycle commitment
C Armstrong, SL Spencer - Proceedings of the National …, 2021 - National Acad Sciences
The current model of replication-dependent (RD) histone biosynthesis posits that RD histone
gene expression is coupled to DNA replication, occurring only in S phase of the cell cycle …
gene expression is coupled to DNA replication, occurring only in S phase of the cell cycle …
RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3′ end processing
The RNA polymerase II (RNAP II) largest subunit contains a C-terminal domain (CTD) with
up to 52 Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 consensus repeats. Serines 2, 5, and 7 are …
up to 52 Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 consensus repeats. Serines 2, 5, and 7 are …
Mechanisms of RNA export and nuclear retention
M Khan, S Hou, M Chen, H Lei - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
With the identification of huge amount of noncoding RNAs in recent years, the concept of
RNA localization has extended from traditional mRNA export to RNA export of mRNA and …
RNA localization has extended from traditional mRNA export to RNA export of mRNA and …
[HTML][HTML] Multiple export mechanisms for mRNAs
M Delaleau, KLB Borden - Cells, 2015 - mdpi.com
Nuclear mRNA export plays an important role in gene expression. We describe the
mechanisms of mRNA export including the importance of mRNP assembly, docking with the …
mechanisms of mRNA export including the importance of mRNP assembly, docking with the …
A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly (A) and histone mRNAs
Metazoan histone mRNAs are unique: their pre-mRNAs contain no introns, and the mRNAs
are not polyadenylated, ending instead in a conserved stem-loop structure. In Drosophila …
are not polyadenylated, ending instead in a conserved stem-loop structure. In Drosophila …
Defective histone supply causes changes in RNA polymerase II elongation rate and cotranscriptional pre-mRNA splicing
S Jimeno-González, L Payán-Bravo… - Proceedings of the …, 2015 - National Acad Sciences
RNA polymerase II (RNAPII) transcription elongation is a highly regulated process that
greatly influences mRNA levels as well as pre-mRNA splicing. Despite many studies in vitro …
greatly influences mRNA levels as well as pre-mRNA splicing. Despite many studies in vitro …