Where biology and traditional polymers meet: The potential of associating sequence-defined polymers for materials science
Polymers with precisely defined monomeric sequences present an exquisite tool for
controlling material properties by harnessing both the robustness of synthetic polymers and …
controlling material properties by harnessing both the robustness of synthetic polymers and …
A field guide to optimizing peptoid synthesis
N-Substituted glycines (peptoids) are a class of peptidomimetic molecules used as materials
for health, environmental, and drug delivery applications. Automated solid-phase synthesis …
for health, environmental, and drug delivery applications. Automated solid-phase synthesis …
Nanopatterned monolayers of bioinspired, sequence-defined polypeptoid brushes for semiconductor/bio interfaces
The ability to control and manipulate semiconductor/bio interfaces is essential to enable
biological nanofabrication pathways and bioelectronic devices. Traditional surface …
biological nanofabrication pathways and bioelectronic devices. Traditional surface …
Structural elucidation of a polypeptoid chain in a crystalline lattice reveals key morphology-directing role of the N-terminus
The ability to engineer synthetic polymers with the same structural precision as
biomacromolecules is crucial to enable the de novo design of robust nanomaterials with …
biomacromolecules is crucial to enable the de novo design of robust nanomaterials with …
Discovery of a Peptoid-Based Nanoparticle Platform for Therapeutic mRNA Delivery via Diverse Library Clustering and Structural Parametrization
ER Webster, NE Peck, JD Echeverri, S Gholizadeh… - ACS …, 2024 - ACS Publications
Nanoparticle-mediated mRNA delivery has emerged as a promising therapeutic modality,
but its growth is still limited by the discovery and optimization of effective and well-tolerated …
but its growth is still limited by the discovery and optimization of effective and well-tolerated …
Sequence modulates polypeptoid hydration water structure and dynamics
We use molecular dynamics simulations to investigate the effect of polypeptoid sequence on
the structure and dynamics of its hydration waters. Polypeptoids provide an excellent …
the structure and dynamics of its hydration waters. Polypeptoids provide an excellent …
pH-Dependent Solution Micellar Structure of Amphoteric Polypeptoid Block Copolymers with Positionally Controlled Ionizable Sites
While solution micellization of ionic block copolymers (BCP) with randomly distributed
ionization sites along the hydrophilic segments has been extensively studied, the roles of …
ionization sites along the hydrophilic segments has been extensively studied, the roles of …
Greener peptoid synthesis in additive-free water-based media
N Soumanou, D Lybye, T Hjelmgaard, S Faure - Green Chemistry, 2023 - pubs.rsc.org
Highly efficient procedures were developed for greener synthesis of sequence-defined
peptoid oligomers. The optimised chain elongation procedure is carried out in water-based …
peptoid oligomers. The optimised chain elongation procedure is carried out in water-based …
[HTML][HTML] The effect of immobilisation strategies on the ability of peptoids to reduce the adhesion of P. aeruginosa strains to contact lenses
Aim Previous studies have demonstrated that contact lenses coated with the antimicrobial
cationic peptide Mel4, a derivative of melimine, can reduce the occurrence of keratitis …
cationic peptide Mel4, a derivative of melimine, can reduce the occurrence of keratitis …
Design, synthesis and antifreeze properties of biomimetic peptoid oligomers
M Zhang, Z Qiu, K Yang, W Zhou, W Liu, J Lu… - Chemical …, 2023 - pubs.rsc.org
Ice crystals can cause great damage. The utilization of antifreeze agents is an efficient
method to prevent or reduce ice crystal formation and growth. Synthetic antifreeze agents …
method to prevent or reduce ice crystal formation and growth. Synthetic antifreeze agents …