Abstract Full-length p53 (p53α) plays a pivotal role in maintaining genomic integrity and
preventing tumor development. Over the years, p53 was found to exist in various isoforms …

Following the serendipitous discovery of the anticancer activity of cisplatin over 50 years
ago, a deep understanding of the chemical and biochemical transformations giving rise to its …

Simple Summary TP53 is one of the most well-known and intensively studied tumor-
suppressor genes. TP53 is also the most commonly mutated gene in cancer. Many TP53 …

Ischemic stroke is a leading cause of morbidity and death, with the outcome largely
determined by the amount of hypoxia-related neuronal death in the affected brain regions …

Abstract Blocking the MDM2/X–P53 protein–protein interaction has been widely recognized
as an attractive therapeutic strategy for the treatment of cancers. Numerous small-molecule …

Abstract N 6-methyladenosine (m 6 A), the most abundant and reversible RNA modification,
plays critical a role in tumorigenesis. However, whether m 6 A can regulate p53, a leading …

The tumor suppressor gene TP53 is the most frequently mutated gene in human cancer. It
encodes p53, a DNA-binding transcription factor that regulates multiple genes involved in …

The increasing incidence of skin cancer (SC) is a global health concern. The commonly
reported side effects and resistance mechanisms have imposed the pursuit for new …

MicroRNA-155 (miR-155) is dysregulated in human cancers. In this study, we reported that
miR-155 was over-expressed in bladder cancer tissues. We found that miR-155 promoted …

Sequence-specific DNA-binding proteins can maintain and regulate cellular functions by
accurately and quickly binding to target sequences among large amounts of nontarget DNA …