[HTML][HTML] Wnt/β-catenin signaling, disease, and emerging therapeutic modalities
The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …
The Wnt pathway: from signaling mechanisms to synthetic modulators
The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …
remarkable conservation of this intercellular signaling cascade throughout metazoan …
Biased receptor signaling in drug discovery
T Kenakin, EL Barker - Pharmacological reviews, 2019 - Elsevier
A great deal of experimental evidence suggests that ligands can stabilize different receptor
active states that go on to interact with cellular signaling proteins to form a range of different …
active states that go on to interact with cellular signaling proteins to form a range of different …
Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
Forward genetic screens with CRISPR–Cas9 genome editing enable high-resolution
detection of genetic vulnerabilities in cancer cells. We conducted genome-wide CRISPR …
detection of genetic vulnerabilities in cancer cells. We conducted genome-wide CRISPR …
Reck and Gpr124 are essential receptor cofactors for Wnt7a/Wnt7b-specific signaling in mammalian CNS angiogenesis and blood-brain barrier regulation
Reck, a GPI-anchored membrane protein, and Gpr124, an orphan GPCR, have been
implicated in Wnt7a/Wnt7b signaling in the CNS vasculature. We show here that vascular …
implicated in Wnt7a/Wnt7b signaling in the CNS vasculature. We show here that vascular …
[HTML][HTML] Next-generation surrogate Wnts support organoid growth and deconvolute frizzled pleiotropy in vivo
Modulation of Wnt signaling has untapped potential in regenerative medicine due to its
essential functions in stem cell homeostasis. However, Wnt lipidation and Wnt-Frizzled (Fzd) …
essential functions in stem cell homeostasis. However, Wnt lipidation and Wnt-Frizzled (Fzd) …
[HTML][HTML] Targeted alveolar regeneration with Frizzled-specific agonists
Summary Wnt ligands oligomerize Frizzled (Fzd) and Lrp5/6 receptors to control the
specification and activity of stem cells in many species. How Wnt signaling is selectively …
specification and activity of stem cells in many species. How Wnt signaling is selectively …
[HTML][HTML] The role of Wnt signalling in angiogenesis
Angiogenesis is a normal biological process wherein new blood vessels form from the
growth of pre-existing blood vessels. Preventing angiogenesis in solid tumours by targeting …
growth of pre-existing blood vessels. Preventing angiogenesis in solid tumours by targeting …
Tumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C
AM Steitz, A Steffes, F Finkernagel, A Unger… - Cell death & …, 2020 - nature.com
A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the
extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites …
extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites …
Wnt/β-catenin signaling as a molecular target by pathogenic bacteria
O Silva-García, JJ Valdez-Alarcón… - Frontiers in …, 2019 - frontiersin.org
The Wnt/β-catenin signaling pathway is crucial to regulate cell proliferation and polarity, cell
determination, and tissue homeostasis. The activation of Wnt/β-catenin signaling is based …
determination, and tissue homeostasis. The activation of Wnt/β-catenin signaling is based …