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Chemistry of MRI contrast agents: current challenges and new frontiers
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …
performed annually around the world. The contrast agents, which improve diagnostic …
Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting
The tumor microenvironment (TME) is emerging as one of the primary barriers in cancer
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …
Extracellular matrix remodeling and cardiac fibrosis
Cardiac fibrosis, characterized by excessive deposition of extracellular matrix (ECM)
proteins in the myocardium, distorts the architecture of the myocardium, facilitates the …
proteins in the myocardium, distorts the architecture of the myocardium, facilitates the …
Myocardial fibrosis: biomedical research from bench to bedside
M Gyöngyösi, J Winkler, I Ramos, QT Do… - European journal of …, 2017 - Wiley Online Library
Myocardial fibrosis refers to a variety of quantitative and qualitative changes in the interstitial
myocardial collagen network that occur in response to cardiac ischaemic insults, systemic …
myocardial collagen network that occur in response to cardiac ischaemic insults, systemic …
Cardiac fibrosis in the pressure overloaded left and right ventricle as a therapeutic target
Myocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …
Right ventricular fibrosis: a pathophysiological factor in pulmonary hypertension?
The role of right ventricular (RV) fibrosis in pulmonary hypertension (PH) remains a subject
of ongoing discussion. Alterations of the collagen network of the extracellular matrix may …
of ongoing discussion. Alterations of the collagen network of the extracellular matrix may …
Surface impact on nanoparticle-based magnetic resonance imaging contrast agents
W Zhang, L Liu, H Chen, K Hu, I Delahunty… - …, 2018 - pmc.ncbi.nlm.nih.gov
Magnetic resonance imaging (MRI) is one of the most widely used diagnostic tools in the
clinic. To improve imaging quality, MRI contrast agents, which can modulate local T1 and T2 …
clinic. To improve imaging quality, MRI contrast agents, which can modulate local T1 and T2 …
Fibrosis and cardiac arrhythmias
In this review article about fibrosis and arrhythmias, we show that the amount of collagen, a
normal element of the heart muscle, increases with age and in heart disease. The relation …
normal element of the heart muscle, increases with age and in heart disease. The relation …
Protein-targeted gadolinium-based magnetic resonance imaging (MRI) contrast agents: design and mechanism of action
Magnetic resonance imaging (MRI) is a powerful medical diagnostic technique: it can
penetrate deep into tissue, provide excellent soft tissue contrast with sub-millimeter …
penetrate deep into tissue, provide excellent soft tissue contrast with sub-millimeter …
Type I collagen–targeted PET probe for pulmonary fibrosis detection and staging in preclinical models
Pulmonary fibrosis is scarring of the lungs that can arise from radiation injury, drug toxicity,
environmental or genetic causes, and for unknown reasons [idiopathic pulmonary fibrosis …
environmental or genetic causes, and for unknown reasons [idiopathic pulmonary fibrosis …