Hypertension affects an estimated 103 million Americans, yet gaps in knowledge continue to
limit its successful management. Rapidly emerging evidence is linking gut dysbiosis to many …

Introduction: Obstructive sleep apnea (OSA) and systemic hypertension (SH) are common
and interrelated diseases. It is estimated that approximately 75% of treatment-resistant …

Background Carotid body (peripheral oxygen sensor) sensitisation is pivotal in the
development of chronic intermittent hypoxia (CIH)-induced hypertension. We sought to …

Sleep-disordered breathing, and particularly the highly prevalent obstructive sleep apnea
syndrome, is a multicomponent disorder combining intermittent hypoxia (IH), sleep …

Sleep apnea (SA) is increasing in prevalence and is commonly comorbid with hypertension.
Chronic intermittent hypoxia is used to model the arterial hypoxemia seen in SA, and …

The respiratory and cardiovascular systems are highly intertwined, both anatomically and
physiologically. Respiratory and cardiovascular neurons are often co-localized in the same …

Sleep is involved in the regulation of major organ functions in the human body, and
disruption of sleep potentially can elicit organ dysfunction. Obstructive sleep apnea (OSA) is …

In the present study, we evaluated the mechanisms underpinning the hypertension
observed in freely moving juvenile rats submitted to chronic intermittent hypoxia (CIH). Male …

The carotid body (CB) plays a main role in the maintenance of the oxygen homeostasis. The
hypoxic stimulation of the CB increases the chemosensory discharge, which in turn elicits …

Chronic intermittent hypoxia (CIH, a model for sleep apnoea) is a major risk factor for several
cardiovascular diseases. Autonomic imbalance (sympathetic overactivity and …