Tubulin, the protein subunit of microtubules (MTs), is an α/β heterodimer. In this chapter, a
hypothesis on the evolution of the tubulin molecule is proposed, based in part on recent …

Microtubules are major components of the cytoskeleton that play important roles in cellular
processes such as intracellular transport and cell division. In recent years, it has become …

Tremendous progress has been made in understanding the functions of γ-tubulin and, in
particular, its role in microtubule nucleation since the publication of its discovery in 1989 …

Tubulin is the target of some of the most widely used and time-honored anticancer tubulin-
binding agents (TBAs). The clinical usefulness of many TBAs has been held back as a result …

Microtubules composed of αβ-tubulin dimers are dynamic cytoskeletal polymers that play
key roles in essential cellular processes such as cell division, organelle positioning …

The expression, cellular distribution, and subcellular sorting of the microtubule (MT)-
nucleating γ-tubulin small complex (γTuSC) proteins, GCP2 and GCP3, were studied in …

Prefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin
CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and …

Background As reported, γ-tubulin (TuBG1) is related to the occurrence and development of
various types of malignant tumors. However, its role in hepatocellular cancer (HCC) is not …

The formation of the nuclear envelope and the subsequent compartmentalization of the
genome is a defining feature of eukaryotes. Traditionally, the nuclear envelope was purely …

Lung adenocarcinoma (LUAD) causes severe cancer death worldwide. E2F2 is a canonical
transcription factor implicated in transcription regulation, cell cycle and tumorigenesis. The …