Shared TIR enzymatic functions regulate cell death and immunity across the tree of life
In the 20th century, researchers studying animal and plant signaling pathways discovered a
protein domain that is shared across diverse innate immune systems: the Toll/interleukin …
protein domain that is shared across diverse innate immune systems: the Toll/interleukin …
Structure, biochemical function, and signaling mechanism of plant NLRs
To counter pathogen invasion, plants have evolved a large number of immune receptors,
including membrane-resident pattern recognition receptors (PRRs) and intracellular …
including membrane-resident pattern recognition receptors (PRRs) and intracellular …
Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity
Plant nucleotide-binding leucine-rich repeat-containing (NLR) receptors with an N-terminal
Toll/interleukin-1 receptor (TIR) domain sense pathogen effectors to enable TIR-encoded …
Toll/interleukin-1 receptor (TIR) domain sense pathogen effectors to enable TIR-encoded …
TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity
A Jia, S Huang, W Song, J Wang, Y Meng, Y Sun, L Xu… - Science, 2022 - science.org
Plant pathogen–activated immune signaling by nucleotide-binding leucine-rich repeat
(NLR) receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain converges on …
(NLR) receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain converges on …
Oligomerization of a plant helper NLR requires cell-surface and intracellular immune receptor activation
Plant disease resistance involves both detection of microbial molecular patterns by cell-
surface pattern recognition receptors and detection of pathogen effectors by intracellular …
surface pattern recognition receptors and detection of pathogen effectors by intracellular …
New biochemical principles for NLR immunity in plants
While working for the United States Department of Agriculture on the North Dakota
Agricultural College campus in Fargo, North Dakota, in the 1940s and 1950s, Harold H. Flor …
Agricultural College campus in Fargo, North Dakota, in the 1940s and 1950s, Harold H. Flor …
EDS1 complexes are not required for PRR responses and execute TNL‐ETI from the nucleus in Nicotiana benthamiana
J Zönnchen, J Gantner, D Lapin, K Barthel… - New …, 2022 - Wiley Online Library
Heterodimeric complexes incorporating the lipase‐like proteins EDS1 with PAD4 or SAG101
are central hubs in plant innate immunity. EDS1 functions encompass signal relay from TIR …
are central hubs in plant innate immunity. EDS1 functions encompass signal relay from TIR …
[HTML][HTML] TIR-domain enzymatic activities at the heart of plant immunity
Abstract Toll/interleukin-1/resistance (TIR) domain proteins contribute to innate immunity in
all cellular kingdoms. TIR modules are activated by self-association and in plants, mammals …
all cellular kingdoms. TIR modules are activated by self-association and in plants, mammals …
Recognition of a salivary effector by the TNL protein RCSP promotes effector‐triggered immunity and systemic resistance in Nicotiana benthamiana
W Rao, T Ma, J Cao, Y Zhang, S Chen… - Journal of Integrative …, 2025 - Wiley Online Library
Insects secret chemosensory proteins (CSPs) into plant cells as potential effector proteins
during feeding. The molecular mechanisms underlying how CSPs activate plant immunity …
during feeding. The molecular mechanisms underlying how CSPs activate plant immunity …
Arabidopsis PHYTOALEXIN DEFICIENT 4 promotes the maturation and nuclear accumulation of immune-related cysteine protease RD19
Y Zeng, Z Zheng, G Hessler, K Zou… - Journal of …, 2024 - academic.oup.com
Abstract Arabidopsis PHYTOALEXIN DEFICIENT 4 (PAD4) has an essential role in
pathogen resistance as a heterodimer with ENHANCED DISEASE SUSCEPTIBILITY 1 …
pathogen resistance as a heterodimer with ENHANCED DISEASE SUSCEPTIBILITY 1 …