Colorectal liver metastasis: molecular mechanism and interventional therapy

H Zhou, Z Liu, Y Wang, X Wen, EH Amador… - Signal transduction and …, 2022 - nature.com
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

[HTML][HTML] MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside

KKW To, CWS Tong, M Wu… - World journal of …, 2018 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are small, single-stranded, noncoding RNAs that can post-
transcriptionally regulate the expression of various oncogenes and tumor suppressor genes …

The multifaceted role of TMEM16A in cancer

D Crottès, LY Jan - Cell Calcium, 2019 - Elsevier
The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over
decades, TMEM16A over-expression and contribution to prognosis have been widely …

TMEM16A as a potential treatment target for head and neck cancer

K Okuyama, S Yanamoto - Journal of Experimental & Clinical Cancer …, 2022 - Springer
Abstract Transmembrane protein 16A (TMEM16A) forms a plasma membrane-localized
Ca2+-activated Cl-channel. Its gene has been mapped to an area on chromosome 11q13 …

Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer

H Wang, L Zou, K Ma, J Yu, H Wu, M Wei, Q **ao - Molecular cancer, 2017 - Springer
TMEM16A (known as anoctamin 1) Ca 2+-activated chloride channel is overexpressed in
many tumors. TMEM16A overexpression can be caused by gene amplification in many …

Recent advances in TMEM16A: Structure, function, and disease

Q Ji, S Guo, X Wang, C Pang, Y Zhan… - Journal of cellular …, 2019 - Wiley Online Library
TMEM16A (also known as anoctamin 1, ANO1) is the molecular basis of the calcium‐
activated chloride channels, with ten transmembrane segments. Recently, atomic structures …

MicroRNA-381 inhibits the metastasis of gastric cancer by targeting TMEM16A expression

Q Cao, F Liu, K Ji, N Liu, Y He, W Zhang… - Journal of Experimental & …, 2017 - Springer
Abstract Background MicroRNA-381 (miR-381) has been reported to play suppressive or
promoting roles in different malignancies. However, the expression level, biological function …

[HTML][HTML] MicroRNAs as novel biomarkers for colorectal cancer: New outlooks

N Shirafkan, B Mansoori, A Mohammadi… - Biomedicine & …, 2018 - Elsevier
Colorectal cancer is one of the most prevalent cancers with high mortality in the world.
MicroRNAs are a class of small non-coding RNAs that regulate gene expression through …

[HTML][HTML] The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?

Y Liu, Z Liu, KW Wang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Abstract Anoctamin 1 (ANO1) or TMEM16A gene encodes a member of Ca 2+ activated Cl–
channels (CaCCs) that are critical for physiological functions, such as epithelial secretion …

LncRNA SNHG5 affects cell proliferation, metastasis and migration of colorectal cancer through regulating miR-132-3p/CREB5

M Zhang, Y Li, H Wang, W Yu, S Lin… - Cancer biology & …, 2019 - Taylor & Francis
We aimed at the effects of long non-coding RNA (lncRNA) SNHG5 on proliferation,
metastasis and migration of colorectal cancer (CRC) cells. We also investigated regulatory …