Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Trauma remains a leading cause of death worldwide, and most early preventable deaths in
both the civilian and military settings are due to uncontrolled hemorrhage, despite paradigm …

Abstract These European Resuscitation Council (ERC) Cardiac Arrest in Special
Circumstances guidelines are based on the 2020 International Consensus on …

Background Time to treatment matters in traumatic haemorrhage but the optimal prehospital
use of blood in major trauma remains uncertain. We investigated whether use of packed red …

The COVID-19 pandemic has major implications for blood transfusion. There are uncertain
patterns of demand, and transfusion institutions need to plan for reductions in donations and …

Importance In-hospital administration of tranexamic acid after injury improves outcomes in
patients at risk for hemorrhage. Data demonstrating the benefit and safety of the pragmatic …

Importance Both military and civilian clinical practice guidelines include early plasma
transfusion to achieve a plasma to red cell ratio approaching 1: 1 to 1: 2. However, it was not …

Importance Although the Afghanistan and Iraq conflicts have the lowest US case-fatality
rates in history, no comprehensive assessment of combat casualty care statistics, major …

Background Major haemorrhage is a clinical emergency that results in morbidity and
mortality: practice guidance is important to reduce these risks. Delayed recognition of …

Coagulopathy is a severe and frequent complication in critically ill patients, for which the
pathogenesis and presentation may be variable depending on the underlying disease …