Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …

Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …

Early and progressive dysfunctions of the dopaminergic system from the Ventral Tegmental
Area (VTA) have been described in Alzheimer's Disease (AD). During the long pre …

Synaptic plasticity plays a central role in the study of neural mechanisms of learning and
memory. Plasticity rules are not invariant over time but are under neuromodulatory control …

Although sensitizing processes occur earlier, schizophrenia is diagnosed in young
adulthood, which suggests that it might involve a pathological transition during late brain …

Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging
studies. The mechanism underlying this is unclear but may be due to N-methyl-D-aspartate …

Modern life poses many threats to good-quality sleep, challenging brain health across the
lifespan. Curtailed or fragmented sleep may be particularly damaging during adolescence …

Over the past twenty years, the reuniens and rhomboid (ReRh) nuclei, which constitute the
ventral midline thalamus, have received constantly growing attention. Since our first review …

According to the glutamate hypothesis of schizophrenia, the abnormality of glutamate
transmission induced by hypofunction of NMDA receptors (NMDARs) is causally associated …

Background Converging evidence implicates the anterior hippocampus in the proximal
pathophysiology of schizophrenia. Although resting state functional connectivity (FC) holds …