In cancer patients, immune cells are often functionally compromised due to the
immunosuppressive features of the tumor microenvironment (TME) which contribute to the …

Purpose Hypoxia (low oxygen) is a common feature of solid tumors that has been intensely
studied for more than six decades. Here we review the importance of hypoxia to …

Populations and species are threatened by human pressure, but their fate is variable. Some
depleted populations, such as that of the northern elephant seal (Mirounga angustirostris) …

R-loops are inherent byproducts of transcription consisting of an RNA: DNA hybrid and a
displaced single-stranded DNA. These structures are of key importance in controlling …

Cancer is a leading cause of death worldwide. As a common characteristic of cancer,
hypoxia is associated with poor prognosis due to enhanced tumor malignancy and …

Three-stranded DNA–RNA structures known as R-loops that form during papillomavirus
transcription can cause transcription–replication conflicts and lead to DNA damage. We …

Hypoxia is a common feature of solid tumors and is associated with poor patient prognosis,
therapy resistance and metastasis. Radiobiological hypoxia (< 0.1% O2) is one of the few …

R-loops are three-stranded DNA/RNA hybrids that form by the annealing of the mRNA
transcript to its coding template while displacing the non-coding strand. While R-loop …

R-loops are by-products of transcription that must be tightly regulated to maintain genomic
stability and gene expression. Here, we describe a mechanism for the regulation of the R …

Hypoxia is a feature of most solid tumours and predicts for poor prognosis. In radiobiological
hypoxia (< 0.1% O2) cells become up to three times more resistant to radiation. The …