Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Artificial ion channels with ion permeability and selectivity comparable to their biological
counterparts are highly desired for efficient separation, biosensing, and energy conversion …

Peptides have been extensively utilized to construct nanomaterials that display targeted
structure through hierarchical assembly. The self-assembly of both rationally designed …

Abstract Information in proteins flows from sequence to structure to function, with each step
causally driven by the preceding one. Protein design is founded on inverting this process …

Protein design has come of age, but how will it mature? In the 1980s and the 1990s, the
primary motivation for de novo protein design was to test our understanding of the …

The precise assembly and engineering of molecular machines capable of handling
biomolecules play crucial roles in most single-molecule methods. In this work we use …

Self-assembled monolayers (SAMs) represent highly ordered molecular materials with
versatile biochemical features and multidisciplinary applications. Research on SAMs has …

The envelope (E) protein of the SARS-CoV-2 virus forms cation-conducting channels in the
endoplasmic reticulum Golgi intermediate compartment (ERGIC) of infected cells. The …

Computational protein design is advancing rapidly. Here we describe efficient routes starting
from validated parallel and antiparallel peptide assemblies to design two families of α …

Transmembrane β-barrels have considerable potential for a broad range of sensing
applications. Current engineering approaches for nanopore sensors are limited to naturally …