The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers
Obsessive compulsive disorder (OCD) is a highly debilitating neuropsychiatric condition with
estimated lifetime prevalence of 2–3%, more than twice that of schizophrenia. However, in …
estimated lifetime prevalence of 2–3%, more than twice that of schizophrenia. However, in …
A dialogue between the immune system and brain, spoken in the language of serotonin
Neuropsychiatric disorders have long been linked to both immune system activation and
alterations in serotonin (5-HT) signaling. In the CNS, the contributions of 5-HT modulate a …
alterations in serotonin (5-HT) signaling. In the CNS, the contributions of 5-HT modulate a …
[HTML][HTML] Serotonin transporter: gene, genetic disorders, and pharmacogenetics
The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire
serotoninergic system and its receptors via mod-ulation of extracellular fluid serotonin …
serotoninergic system and its receptors via mod-ulation of extracellular fluid serotonin …
The genetics of obsessive-compulsive disorder: a review
DL Pauls - Dialogues in clinical neuroscience, 2010 - Taylor & Francis
Obsessive-compulsive disorder (OCD) is a serious psychiatric disorder that affects
approximately 2% of the populations of children and adults. Family aggregation studies …
approximately 2% of the populations of children and adults. Family aggregation studies …
Gene–environment interaction and the genetics of depression
Depression is a group of brain disorders with varied origins, complex genetics and obscure
neurobiology. Definitions of clinical phenotypes are not rooted in their neurobiology, and …
neurobiology. Definitions of clinical phenotypes are not rooted in their neurobiology, and …
Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample
Abstract The serotonin transporter (5‐HTT) regulates serotonergic neurotransmission and is
thought to influence emotion. A 5‐HTT‐linked polymorphic region (5‐HTTLPR) has two …
thought to influence emotion. A 5‐HTT‐linked polymorphic region (5‐HTTLPR) has two …
Pharmacogenetics and the serotonin system: initial studies and future directions
Serotonin (5-hydroxytryptamine, 5-HT) appears to play a role in the pathophysiology of a
range of neuropsychiatric disorders, and serotonergic agents are of central importance in …
range of neuropsychiatric disorders, and serotonergic agents are of central importance in …
Obsessive-compulsive disorder phenotypes: implications for genetic studies
Obsessive-compulsive disorder (OCD) clinical presentation is remarkably diverse, and can
vary both within and across patients over time. This variability in the phenotypic expression …
vary both within and across patients over time. This variability in the phenotypic expression …
Genome‐wide linkage analysis of families with obsessive‐compulsive disorder ascertained through pediatric probands
The goal of this study was to identify chromosomal regions likely to contain susceptibility
alleles for early‐onset obsessive‐compulsive disorder (OCD). A genome scan was done in …
alleles for early‐onset obsessive‐compulsive disorder (OCD). A genome scan was done in …
Pharmacotherapy of obsessive-compulsive disorder and obsessive-compulsive spectrum disorders
In addition to the open-mindedness of the authors, the surprising content of these
hypotheses illustrates how dramatically the attitude towards OCS has shifted in a few …
hypotheses illustrates how dramatically the attitude towards OCS has shifted in a few …