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Hallmarks of neurodegenerative diseases
Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …
Tissue-specific macrophages: how they develop and choreograph tissue biology
Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
cGAS–STING drives ageing-related inflammation and neurodegeneration
Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated
impairment and disease. Multiple factors can contribute to ageing-associated inflammation; …
impairment and disease. Multiple factors can contribute to ageing-associated inflammation; …
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy
Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …
Role of neuroinflammation in neurodegeneration development
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
[HTML][HTML] Microglia states and nomenclature: A field at its crossroads
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
Neuroinflammation in Alzheimer disease
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …
Synaptic degeneration in Alzheimer disease
Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …
individuals accompanied by the presence of two pathological protein aggregates—amyloid …
Applications of single-cell RNA sequencing in drug discovery and development
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …
together with associated computational tools and the growing availability of public data …